Hyperpolarized metabolic MR in the study of cardiac function and disease

M. H. Lauritzen, L. V. Søgaard, Pia Lisbeth Madsen, Jan Henrik Ardenkjær-Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Several diseases of the heart have been linked to an insufficient ability to generate enough energy (ATP) to sustain proper heart function. Hyperpolarized magnetic resonance (MR) is a novel technique that can visualize and quantify myocardial energy metabolism. Hyperpolarization enhances the MR signal from a biological molecule of interest by more than 10,000 times, making it possible to measure its cellular uptake and conversion in specific enzymatic pathways in real time. We review the role of hyperpolarized MR in identifying changes in cardiac metabolism in vivo, and present the extensive literature on hyperpolarized pyruvate that has been used to characterize cardiac disease in various in vivo models, such as myocardial ischemia, hypertension, diabetes, hyperthyroidism and heart failure. The technical aspects of the technique are presented as well as the challenges of translating the technique into clinical practice. Hyperpolarized MR has the prospect of transforming diagnostic cardiology by offering new insights into cardiac disease and potentially even to contribute to personalized therapy based on a thorough understanding of the individual intracellular metabolism.
Original languageEnglish
JournalCurrent Pharmaceutical Design
Volume20
Issue number39
Pages (from-to)6162-6170
ISSN1381-6128
Publication statusPublished - 2014

Keywords

  • Drug Discovery
  • Pharmacology
  • 13C
  • Cardiac metabolism
  • Hyperpolarization
  • Magnetic resonance spectroscopy
  • Pyruvate
  • 1 acetate c 13
  • 1 propionate c 13
  • 1 pyruvate c 13
  • 2 pyruvate c 13
  • adenosine triphosphate
  • bicarbonate c 13
  • fatty acid
  • glucose
  • nuclear magnetic resonance imaging agent
  • oxygen
  • pyruvic acid
  • unclassified drug
  • Article
  • clinical practice
  • diabetes mellitus
  • glucose metabolism
  • heart disease
  • heart failure
  • heart function
  • heart muscle contractility
  • heart muscle ischemia
  • heart muscle metabolism
  • human
  • hyperpolarization
  • hypertension
  • hyperthyroidism
  • nonhuman
  • nuclear magnetic resonance spectroscopy
  • oxidation
  • personalized medicine

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