Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and Applications

Jan H. Ardenkjaer-Larsen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

The basic principles of dissolution dynamic nuclear polarization (dDNP) will be described with the aim to hyperpolarize nuclear spins for in vivo magnetic resonance imaging and its applications. Hyperpolarization signifies a strong, nonequilibrium nuclear spin polarization, and as a consequence, a strong enhancement of the available magnetic resonance signal. dDNP is one of several methods to hyperpolarize nuclear spins in the liquid state, and the most general. However, hyperpolarization and dDNP have some limitations that will be discussed. It requires a device, the polarizer, to create the solution of hyperpolarized nuclear spins. The device and pharmaceutical requirements for clinical translation are presented. We will discuss the implications of imaging strong, nonequilibrium nuclear spin polarization from a pulse sequence and scanner perspective. 13C-labeled pyruvate is the first agent to be introduced clinically and progress toward the application of hyperpolarized 13C metabolic imaging in oncology, cardiology, and neurology are reviewed.

Original languageEnglish
Title of host publicationMolecular Imaging : Principles and Practice
PublisherElsevier
Publication date2021
Edition2
Pages563-581
Chapter31
ISBN (Print)9780128163870
ISBN (Electronic)9780128163863
DOIs
Publication statusPublished - 2021

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