Hyperpolarized 2-oxoglutarate as metabolic agent in mr

Pernille Rose Jensen (Inventor), Magnus Karlsson (Inventor), Mathilde Hauge Lerche (Inventor), Claudia Cabella (Inventor), Lara Caminiti (Inventor), Sonia Colombo Serra (Inventor), Luigi Miragoli (Inventor), Luisa Poggi (Inventor), Luca Venturi (Inventor), Fabio Tedoldi (Inventor)

Research output: Patent

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Abstract

Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy
Original languageEnglish
IPCA61K 49/ 10 A I
Patent numberEP2911704
Filing date02/09/2015
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date24/10/2013
Priority numberWO2013EP72269
Publication statusPublished - 2 Sep 2015

Bibliographical note

Also published as: WO2014064194 (A1) US2015273086 (A1)

Cite this

Jensen, P. R., Karlsson, M., Lerche, M. H., Cabella, C., Caminiti, L., Colombo Serra, S., Miragoli, L., Poggi, L., Venturi , L., & Tedoldi, F. (2015). IPC No. A61K 49/ 10 A I. Hyperpolarized 2-oxoglutarate as metabolic agent in mr. (Patent No. EP2911704).