Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy
|IPC||A61K 49/ 10 A I|
|Country||International Bureau of the World Intellectual Property Organization (WIPO)|
|Publication status||Published - 2 Sep 2015|
Also published as: WO2014064194 (A1) US2015273086 (A1)
Jensen, P. R., Karlsson, M., Lerche, M. H.
, Cabella, C., Caminiti, L., Colombo Serra, S., Miragoli, L., Poggi, L., Venturi , L., & Tedoldi, F. (2015). IPC No. A61K 49/ 10 A I. Hyperpolarized 2-oxoglutarate as metabolic agent in mr
. (Patent No. EP2911704