Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Pernille Rose Jensen; Sebastian Meier

doi:10.1039/C5CC09790H

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Pernille Rose Jensen, Sebastian Meier

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Abstract

Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet ¹³C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised¹³Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.

Original language	English
Journal	Chemical Communications
Volume	52
Pages (from-to)	2288-2291
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/C5CC09790H
Publication status	Published - 2016

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title = "Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH",

abstract = "Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.",

author = "Jensen, {Pernille Rose} and Sebastian Meier",

year = "2016",

doi = "10.1039/C5CC09790H",

language = "English",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Jensen, Pernille Rose

AU - Meier, Sebastian

PY - 2016

Y1 - 2016

N2 - Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.

AB - Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.

U2 - 10.1039/C5CC09790H

DO - 10.1039/C5CC09790H

M3 - Journal article

VL - 52

SP - 2288

EP - 2291

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

ER -

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Abstract

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