Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

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Abstract

Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.
Original languageEnglish
JournalChemical Communications
Volume52
Pages (from-to)2288-2291
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 2016

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