Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Pernille Rose Jensen; Sebastian Meier

doi:10.1039/C5CC09790H

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

Pernille Rose Jensen, Sebastian Meier

Department of Chemistry

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Abstract

Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet ¹³C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised¹³Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.

Original language	English
Journal	Chemical Communications
Volume	52
Pages (from-to)	2288-2291
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/C5CC09790H
Publication status	Published - 2016

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title = "Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH",

abstract = "Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.",

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AU - Meier, Sebastian

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AB - Organic phosphate metabolites contain functional groups withpKa values near the physiologic pH range, yielding pH-dependet 13C chemical shift changes of adjacent quaternary carbon sites.Whenformed in defined cellular compartmentsfrom exogenoushyperpolarised13Csubstrates,metabolites thuscanyieldlocalisedpHvalues and correlationsoforganellepH and catalyticactivity.

U2 - 10.1039/C5CC09790H

DO - 10.1039/C5CC09790H

M3 - Journal article

SN - 1359-7345

VL - 52

SP - 2288

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JO - Chemical Communications

JF - Chemical Communications

ER -

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

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