Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

Trine Stavngaard, Lise Vejby Søgaard, Jann Mortensen, Lars G. Hanson, Jörg Schmiedeskamp, Anne Kiil Berthelsen, Asger Dirksen

Research output: Contribution to journalJournal articleResearchpeer-review


Purpose: During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. Methods: HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. Results: We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p
Keyword: Krypton SPECT,Ventilation,MRI,Lung,Hyperpolarisation
Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number4
Pages (from-to)448-457
Publication statusPublished - 2005
Externally publishedYes


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