Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

Trine Stavngaard; Lise Vejby Søgaard; Jann Mortensen; Lars G.  Hanson; Jörg Schmiedeskamp; Anne Kiil Berthelsen; Asger Dirksen

doi:10.1007/s00259-004-1691-x

Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

Trine Stavngaard, Lise Vejby Søgaard, Jann Mortensen, Lars G. Hanson, Jörg Schmiedeskamp, Anne Kiil Berthelsen, Asger Dirksen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Purpose: During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. Methods: HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. Results: We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p
Keyword: Krypton SPECT,Ventilation,MRI,Lung,Hyperpolarisation

Original language	English
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	32
Issue number	4
Pages (from-to)	448-457
ISSN	1619-7070
DOIs	https://doi.org/10.1007/s00259-004-1691-x
Publication status	Published - 2005
Externally published	Yes

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title = "Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease",

abstract = "Purpose: During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. Methods: HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. Results: We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p Keyword: Krypton SPECT,Ventilation,MRI,Lung,Hyperpolarisation",

author = "Trine Stavngaard and S{\o}gaard, {Lise Vejby} and Jann Mortensen and Hanson, {Lars G.} and J{\"o}rg Schmiedeskamp and Berthelsen, {Anne Kiil} and Asger Dirksen",

year = "2005",

doi = "10.1007/s00259-004-1691-x",

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T1 - Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

AU - Stavngaard, Trine

AU - Søgaard, Lise Vejby

AU - Mortensen, Jann

AU - Hanson, Lars G.

AU - Schmiedeskamp, Jörg

AU - Berthelsen, Anne Kiil

AU - Dirksen, Asger

PY - 2005

Y1 - 2005

N2 - Purpose: During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. Methods: HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. Results: We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p Keyword: Krypton SPECT,Ventilation,MRI,Lung,Hyperpolarisation

AB - Purpose: During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. Methods: HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. Results: We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p Keyword: Krypton SPECT,Ventilation,MRI,Lung,Hyperpolarisation

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DO - 10.1007/s00259-004-1691-x

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SN - 1619-7070

VL - 32

SP - 448

EP - 457

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 4

ER -

Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

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