Hydrodynamic Characterization of Substrate Gradients in a Pilot Scale Fermenter Using CFD and Spatially Distributed Sensors

Christian Bach, Mads Orla Albæk, Ulrich Krühne, Krist V. Gernaey

Research output: Contribution to conferencePosterResearchpeer-review

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Abstract

The prediction and understanding of mixing and oxygen mass transfer in fermenters and bioreactors is useful for bioprocess improvement as these dynamics govern production rates of the biotransformation. In particular heterogeneities occurring under process conditions is of interest as such gradients present challenges for process development and scale up [1]. Heterogeneities in substrate concentration have been identified in large scale fermenters [2] and reliable tools to identify and quantify these phenomena are required. This work utilizes the degradation of hydrogen peroxide to oxygen by catalase to illustrate and validate how substrate is distributed throughout the vessel by combining CFD and experimental data collected with spatially distributed sensors.
Original languageEnglish
Publication date2015
Number of pages1
Publication statusPublished - 2015
EventRecent Advances in Fermentation Technology 2015 - Hilton Clearwater Beach Hotel, Clearwater Beach, United States
Duration: 8 Nov 201511 Nov 2015
Conference number: 11
https://sim.confex.com/sim/raft11/webprogram/meeting.html

Conference

ConferenceRecent Advances in Fermentation Technology 2015
Number11
LocationHilton Clearwater Beach Hotel
Country/TerritoryUnited States
CityClearwater Beach
Period08/11/201511/11/2015
Internet address

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