Hydrazidomycins, cytotoxic alkylhydrazides from Streptomyces atratus

Nico Ueberschaar, Basile Le Sage Tchize Ndejouong, Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomyces atratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC50 = 0.37 µM). 
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume21
Issue number19
Pages (from-to)5839-5841
Number of pages3
ISSN0960-894X
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Cytotoxic
  • Hydrazide
  • Hydrazidomycin
  • Natural product
  • Streptomyces atratus

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