Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol % of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of −35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.
Original languageEnglish
JournalAcs Applied Bio Materials
Volume2
Issue number10
Pages (from-to)4154-4161
ISSN2576-6422
DOIs
Publication statusPublished - 2019

Keywords

  • Blood compatible polymer
  • Hydrogen bonding
  • Poly(2-methoxyethyl acrylate)
  • Free-standing film
  • Intermediate water
  • 2-{3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido}ethyl methacrylate

Cite this

Jankova, Katja ; Javakhishvili, Irakli ; Kobayashi, Shingo ; Koguchi, Ryohei ; Murakami, Daiki ; Sonoda, Toshiki ; Tanaka, Masaru. / Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate). In: Acs Applied Bio Materials. 2019 ; Vol. 2, No. 10. pp. 4154-4161.
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title = "Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)",
abstract = "The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol {\%} of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of −35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.",
keywords = "Blood compatible polymer, Hydrogen bonding, Poly(2-methoxyethyl acrylate), Free-standing film, Intermediate water, 2-{3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido}ethyl methacrylate",
author = "Katja Jankova and Irakli Javakhishvili and Shingo Kobayashi and Ryohei Koguchi and Daiki Murakami and Toshiki Sonoda and Masaru Tanaka",
year = "2019",
doi = "10.1021/acsabm.9b00363",
language = "English",
volume = "2",
pages = "4154--4161",
journal = "Acs Applied Bio Materials",
issn = "2576-6422",
publisher = "American Chemical Society",
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Jankova, K, Javakhishvili, I, Kobayashi, S, Koguchi, R, Murakami, D, Sonoda, T & Tanaka, M 2019, 'Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)', Acs Applied Bio Materials, vol. 2, no. 10, pp. 4154-4161. https://doi.org/10.1021/acsabm.9b00363

Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate). / Jankova, Katja; Javakhishvili, Irakli; Kobayashi, Shingo; Koguchi, Ryohei; Murakami, Daiki; Sonoda, Toshiki; Tanaka, Masaru.

In: Acs Applied Bio Materials, Vol. 2, No. 10, 2019, p. 4154-4161.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

AU - Jankova, Katja

AU - Javakhishvili, Irakli

AU - Kobayashi, Shingo

AU - Koguchi, Ryohei

AU - Murakami, Daiki

AU - Sonoda, Toshiki

AU - Tanaka, Masaru

PY - 2019

Y1 - 2019

N2 - The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol % of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of −35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.

AB - The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol % of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of −35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.

KW - Blood compatible polymer

KW - Hydrogen bonding

KW - Poly(2-methoxyethyl acrylate)

KW - Free-standing film

KW - Intermediate water

KW - 2-{3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido}ethyl methacrylate

U2 - 10.1021/acsabm.9b00363

DO - 10.1021/acsabm.9b00363

M3 - Journal article

VL - 2

SP - 4154

EP - 4161

JO - Acs Applied Bio Materials

JF - Acs Applied Bio Materials

SN - 2576-6422

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ER -