Hybrid electrospun chitosan-phospholipids nanofibers for transdermal drug delivery

Ana Carina Loureiro Mendes, Christian Gorzelanny, Natalia Halter, Stefan W. Schneider, Ioannis S. Chronakis

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Chitosan (Ch) polysaccharide was mixed with phospholipids (P) to generate electrospun hybrid nanofibers intended to be used as platforms for transdermal drug delivery. Ch/P nanofibers exibithed average diameters ranging from 248 +/- 94 nm to 600 +/- 201 nm, depending on the amount of phospholipids used. Fourier Transformed Infra-Red (FTIR) spectroscopy and Dynamic Light Scattering (DLS) data suggested the occurrence of electrostatic interactions between amine groups of chitosan with the phospholipid counterparts. The nanofibers were shown to be stable for at least 7 days in Phosphate Buffer Saline (PBS) solution. Cytotoxicity studies (WST-1 and LDH assays) demonstrated that the hybrid nanofibers have suitable biocompatibility. Fluorescence microscopy, also suggested that L929 cells seeded on top of the CH/P hybrid have similar metabolic activity comparatively to the cells seeded on tissue culture plate (control). The release of curcumin, diclofenac and vitamin B12, as model drugs, from Ch/P hybrid nanofibers was investigated, demonstrating their potential utilization as a transdermal drug delivery system.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume510
Issue number1
Pages (from-to)48-56
Number of pages9
ISSN0378-5173
DOIs
Publication statusPublished - 2016

Keywords

  • Electrospinning
  • Nanofibers
  • Transdermal drug delivery
  • Chitosan
  • Phospholipids
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Hybrid electrospun chitosan-phospholipids nanofibers for transdermal drug delivery'. Together they form a unique fingerprint.

Cite this