Human oligoclonal recombinant antivenom against the black mamba (Dendroaspis polylepis)

Andreas Hougaard Laustsen; Aneesh Karatt-­Vellatt; Peter Slavny; Alice M. Luther; Majken L. Olesen; Edward W. Masters; Bruno Lomonte; José María Gutiérrez; John McCafferty

Human oligoclonal recombinant antivenom against the black mamba (Dendroaspis polylepis)

Andreas Hougaard Laustsen, Aneesh Karatt-Vellatt, Peter Slavny, Alice M. Luther, Majken L. Olesen, Edward W. Masters, Bruno Lomonte, José María Gutiérrez, John McCafferty

Research output: Contribution to conference › Poster › Research › peer-review

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Abstract

Snakebite envenoming is a major cause of death and morbidity in tropical parts of the world. Current therapies are based on animal-derived antisera that are associated with a high degree of immunogenicity, high cost, and batch-to-batch variation. Here, we report the results of our ongoing efforts of developing the world’s first fully recombinant antivenom based on human IgGs targeting the key toxins from the notorious black mamba (Dendroaspis polylepis).

Original language	English
Publication date	2016
Number of pages	1
Publication status	Published - 2016
Event	PEGS Europe: Protein & Antibody Engineering Summit 2016 - Lisbon, Portugal Duration: 31 Oct 2016 → 4 Nov 2016

Conference

Conference	PEGS Europe: Protein & Antibody Engineering Summit 2016
Country	Portugal
City	Lisbon
Period	31/10/2016 → 04/11/2016

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Laustsen, Andreas Hougaard ; Karatt-Vellatt, Aneesh ; Slavny, Peter ; M. Luther, Alice ; L. Olesen, Majken ; W. Masters, Edward ; Lomonte, Bruno ; Gutiérrez, José María ; McCafferty, John. / Human oligoclonal recombinant antivenom against the black mamba (Dendroaspis polylepis). Poster session presented at PEGS Europe: Protein & Antibody Engineering Summit 2016, Lisbon, Portugal.1 p.

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author = "Laustsen, {Andreas Hougaard} and Aneesh Karatt-Vellatt and Peter Slavny and {M. Luther}, Alice and {L. Olesen}, Majken and {W. Masters}, Edward and Bruno Lomonte and Guti{\'e}rrez, {Jos{\'e} Mar{\'i}a} and John McCafferty",

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language = "English",

note = "PEGS Europe: Protein & Antibody Engineering Summit 2016 ; Conference date: 31-10-2016 Through 04-11-2016",

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Human oligoclonal recombinant antivenom against the black mamba (Dendroaspis polylepis). / Laustsen, Andreas Hougaard; Karatt-Vellatt, Aneesh; Slavny, Peter; M. Luther, Alice; L. Olesen, Majken; W. Masters, Edward; Lomonte, Bruno; Gutiérrez, José María; McCafferty, John.

2016. Poster session presented at PEGS Europe: Protein & Antibody Engineering Summit 2016, Lisbon, Portugal.

Research output: Contribution to conference › Poster › Research › peer-review

TY - CONF

T1 - Human oligoclonal recombinant antivenom against the black mamba (Dendroaspis polylepis)

AU - Laustsen, Andreas Hougaard

AU - Karatt-Vellatt, Aneesh

AU - Slavny, Peter

AU - M. Luther, Alice

AU - L. Olesen, Majken

AU - W. Masters, Edward

AU - Lomonte, Bruno

AU - Gutiérrez, José María

AU - McCafferty, John

PY - 2016

Y1 - 2016

N2 - Snakebite envenoming is a major cause of death and morbidity in tropical parts of the world. Current therapies are based on animal-derived antisera that are associated with a high degree of immunogenicity, high cost, and batch-to-batch variation. Here, we report the results of our ongoing efforts of developing the world’s first fully recombinant antivenom based on human IgGs targeting the key toxins from the notorious black mamba (Dendroaspis polylepis).

AB - Snakebite envenoming is a major cause of death and morbidity in tropical parts of the world. Current therapies are based on animal-derived antisera that are associated with a high degree of immunogenicity, high cost, and batch-to-batch variation. Here, we report the results of our ongoing efforts of developing the world’s first fully recombinant antivenom based on human IgGs targeting the key toxins from the notorious black mamba (Dendroaspis polylepis).

M3 - Poster

T2 - PEGS Europe: Protein & Antibody Engineering Summit 2016

Y2 - 31 October 2016 through 4 November 2016

ER -