Human biomonitoring in health risk assessment in Europe

Current practices and recommendations for the future

Henriqueta Louro, Milla Heinälä, Jos Bessems, Jurgen Buekers, Theo Vermeire, Marjolijn Woutersen, Jacqueline van Engelen, Teresa Borges, Christophe Rousselle, Eva Ougier, Paula Alvito, Carla Martins, Ricardo Assunção, Maria João Silva, Anjoeka Pronk, Bernice Schaddelee-Scholten, Maria Del Carmen Gonzalez, Mercedes de Alba, Argelia Castaño, Susana Viegas & 7 others Tatjana Humar-Juric, Lijana Kononenko, Alfonso Lampen, Anne Marie Vinggaard, Greet Schoeters, Marike Kolossa-Gehring, Tiina Santonen*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017–2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).

Original languageEnglish
JournalInternational Journal of Hygiene and Environmental Health
Volume222
Issue number5
Pages (from-to)727-737
ISSN1438-4639
DOIs
Publication statusPublished - 2019

Keywords

  • Chemicals
  • HBM4EU
  • Human biomonitoring
  • Internal exposure
  • Risk assessment

Cite this

Louro, Henriqueta ; Heinälä, Milla ; Bessems, Jos ; Buekers, Jurgen ; Vermeire, Theo ; Woutersen, Marjolijn ; van Engelen, Jacqueline ; Borges, Teresa ; Rousselle, Christophe ; Ougier, Eva ; Alvito, Paula ; Martins, Carla ; Assunção, Ricardo ; Silva, Maria João ; Pronk, Anjoeka ; Schaddelee-Scholten, Bernice ; Del Carmen Gonzalez, Maria ; de Alba, Mercedes ; Castaño, Argelia ; Viegas, Susana ; Humar-Juric, Tatjana ; Kononenko, Lijana ; Lampen, Alfonso ; Vinggaard, Anne Marie ; Schoeters, Greet ; Kolossa-Gehring, Marike ; Santonen, Tiina. / Human biomonitoring in health risk assessment in Europe : Current practices and recommendations for the future. In: International Journal of Hygiene and Environmental Health. 2019 ; Vol. 222, No. 5. pp. 727-737.
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abstract = "Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017–2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).",
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author = "Henriqueta Louro and Milla Hein{\"a}l{\"a} and Jos Bessems and Jurgen Buekers and Theo Vermeire and Marjolijn Woutersen and {van Engelen}, Jacqueline and Teresa Borges and Christophe Rousselle and Eva Ougier and Paula Alvito and Carla Martins and Ricardo Assun{\cc}{\~a}o and Silva, {Maria Jo{\~a}o} and Anjoeka Pronk and Bernice Schaddelee-Scholten and {Del Carmen Gonzalez}, Maria and {de Alba}, Mercedes and Argelia Casta{\~n}o and Susana Viegas and Tatjana Humar-Juric and Lijana Kononenko and Alfonso Lampen and Vinggaard, {Anne Marie} and Greet Schoeters and Marike Kolossa-Gehring and Tiina Santonen",
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Louro, H, Heinälä, M, Bessems, J, Buekers, J, Vermeire, T, Woutersen, M, van Engelen, J, Borges, T, Rousselle, C, Ougier, E, Alvito, P, Martins, C, Assunção, R, Silva, MJ, Pronk, A, Schaddelee-Scholten, B, Del Carmen Gonzalez, M, de Alba, M, Castaño, A, Viegas, S, Humar-Juric, T, Kononenko, L, Lampen, A, Vinggaard, AM, Schoeters, G, Kolossa-Gehring, M & Santonen, T 2019, 'Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future', International Journal of Hygiene and Environmental Health, vol. 222, no. 5, pp. 727-737. https://doi.org/10.1016/j.ijheh.2019.05.009

Human biomonitoring in health risk assessment in Europe : Current practices and recommendations for the future. / Louro, Henriqueta; Heinälä, Milla; Bessems, Jos; Buekers, Jurgen; Vermeire, Theo; Woutersen, Marjolijn; van Engelen, Jacqueline; Borges, Teresa; Rousselle, Christophe; Ougier, Eva; Alvito, Paula; Martins, Carla; Assunção, Ricardo; Silva, Maria João; Pronk, Anjoeka; Schaddelee-Scholten, Bernice; Del Carmen Gonzalez, Maria; de Alba, Mercedes; Castaño, Argelia; Viegas, Susana; Humar-Juric, Tatjana; Kononenko, Lijana; Lampen, Alfonso; Vinggaard, Anne Marie; Schoeters, Greet; Kolossa-Gehring, Marike; Santonen, Tiina.

In: International Journal of Hygiene and Environmental Health, Vol. 222, No. 5, 2019, p. 727-737.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Human biomonitoring in health risk assessment in Europe

T2 - Current practices and recommendations for the future

AU - Louro, Henriqueta

AU - Heinälä, Milla

AU - Bessems, Jos

AU - Buekers, Jurgen

AU - Vermeire, Theo

AU - Woutersen, Marjolijn

AU - van Engelen, Jacqueline

AU - Borges, Teresa

AU - Rousselle, Christophe

AU - Ougier, Eva

AU - Alvito, Paula

AU - Martins, Carla

AU - Assunção, Ricardo

AU - Silva, Maria João

AU - Pronk, Anjoeka

AU - Schaddelee-Scholten, Bernice

AU - Del Carmen Gonzalez, Maria

AU - de Alba, Mercedes

AU - Castaño, Argelia

AU - Viegas, Susana

AU - Humar-Juric, Tatjana

AU - Kononenko, Lijana

AU - Lampen, Alfonso

AU - Vinggaard, Anne Marie

AU - Schoeters, Greet

AU - Kolossa-Gehring, Marike

AU - Santonen, Tiina

PY - 2019

Y1 - 2019

N2 - Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017–2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).

AB - Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017–2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).

KW - Chemicals

KW - HBM4EU

KW - Human biomonitoring

KW - Internal exposure

KW - Risk assessment

U2 - 10.1016/j.ijheh.2019.05.009

DO - 10.1016/j.ijheh.2019.05.009

M3 - Review

VL - 222

SP - 727

EP - 737

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 5

ER -