Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Research output: Contribution to journalReview – Annual report year: 2019Researchpeer-review

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DOI

  • Author: Louro, Henriqueta

    NOVA University Lisbon

  • Author: Heinälä, Milla

    Finnish Institute of Occupational Health

  • Author: Bessems, Jos

    Flemish Institute for Technological Research

  • Author: Buekers, Jurgen

    Flemish Institute for Technological Research

  • Author: Vermeire, Theo

    National Institute for Public Health and the Environment

  • Author: Woutersen, Marjolijn

    National Institute for Public Health and the Environment

  • Author: van Engelen, Jacqueline

    National Institute for Public Health and the Environment

  • Author: Borges, Teresa

    Ministry of Health

  • Author: Rousselle, Christophe

    ANSES - French Agency for Food, Environmental and Occupational Health & Safety

  • Author: Ougier, Eva

    ANSES - French Agency for Food, Environmental and Occupational Health & Safety

  • Author: Alvito, Paula

    University of Aveiro

  • Author: Martins, Carla

    University of Aveiro

  • Author: Assunção, Ricardo

    University of Aveiro

  • Author: Silva, Maria João

    National Institute of Health Dr. Ricardo Jorge

  • Author: Pronk, Anjoeka

    Netherlands Organisation for Applied Scientific Research

  • Author: Schaddelee-Scholten, Bernice

    Netherlands Organisation for Applied Scientific Research

  • Author: Del Carmen Gonzalez, Maria

    Instituto de Salud Carlos III

  • Author: de Alba, Mercedes

    Instituto de Salud Carlos III

  • Author: Castaño, Argelia

    Instituto de Salud Carlos III

  • Author: Viegas, Susana

    NOVA University Lisbon

  • Author: Humar-Juric, Tatjana

    Ministry of Health

  • Author: Kononenko, Lijana

    Ministry of Health

  • Author: Lampen, Alfonso

    Federal Institute for Risk Assessment

  • Author: Vinggaard, Anne Marie

    Copenhagen Center for Health Technology, Centers, Research group for Molecular and Reproductive Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Schoeters, Greet

    Flemish Institute for Technological Research

  • Author: Kolossa-Gehring, Marike

    German Environment Agency

  • Author: Santonen, Tiina

    Finnish Institute of Occupational Health

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Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017–2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).

Original languageEnglish
JournalInternational Journal of Hygiene and Environmental Health
Volume222
Issue number5
Pages (from-to)727-737
ISSN1438-4639
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Chemicals, HBM4EU, Human biomonitoring, Internal exposure, Risk assessment

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