How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish

Marco A Vindas, Marnix Gorissen, Erik Höglund, Gert Flik, Valentina Tronci, Børge Damsgård, Per-Ove Thörnqvist, Tom O. Nilsen, Svante Winberg, Øyvind Øverli, Lars O. E. Ebbesson

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Abstract

Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternate stress coping styles is poor. Since perception of salient stimuli associated with stress coping in mammals is mainly under forebrain limbic control, we tested region-specific forebrain neural (i.e mRNA abundance and monoamine neurochemistry) and endocrine responses at basal and acute stress conditions for previously characterised proactive and reactive Atlantic salmon. Reactive fish show a higher degree of the neurogenesis marker proliferating cell nuclear antigen (pcna) and dopamine activity under basal conditions in Dl (proposed hippocampus homologue) and higher post-stress plasma cortisol levels. Proactive fish displayed post-stress higher serotonergic signalling (i.e. higher serotonergic activity and expression of the 5-HT1A receptor abundance) in the proposed amygdala homologue (Dm), increased expression of the neuroplasticity marker brain derived neurotropic factor (bdnf) in both Dl and Vv (lateral septum homologue), as well as increased expression of the corticotropin releasing factor 1 (crf1) receptor in the Dl, in line with active coping neuro-profiles reported in the mammalian literature. We present novel evidence of proposed functional equivalences in the fish forebrain with mammalian limbic structures.
Original languageEnglish
JournalJournal of Experimental Biology
Volume220
Issue number8
Pages (from-to)1524-1532
ISSN0022-0949
DOIs
Publication statusPublished - 2017

Keywords

  • Atlantic salmon
  • BDNF
  • limbic areas
  • neural plasticity
  • serotonin

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