In this project, lipid monolayers at air/water interfaces and lipid-bilayer membranes are used as templates for studying the interaction of peptides and amphiphilic proteins with lipid aggregates. This experimental investigation is related to modelstudies of biological membrane structure and -function. Several scattering techniques (small-angle neutron scattering, small-angle X-ray scattering, and grazing-angle X-ray and neutron reflection) are used to investigate trans-layer and lateral structuresof these systems, with particular attention paid to penetration of macromolecules into the lipid layers, assembly, and array formation of proteins and peptides, in monolayers as well as in bilayers. Reconstitution of specific membrane proteins (e.g.anion channels and certain receptors) into lipid layers is part of this study.
|Publication status||Published - 1999|
|Event||Workshop: Pathways in protein folding and protein aggregation - University of Copenhagen, Copenhagen, Denmark|
Duration: 6 Oct 1999 → 9 Oct 1999
|Workshop||Workshop: Pathways in protein folding and protein aggregation|
|Location||University of Copenhagen|
|Period||06/10/1999 → 09/10/1999|