Hot embossing and mechanical punching of biodegradable microcontainers for oral drug delivery

Ritika Singh Petersen, Rasoul Mahshid, Nis Korsgaard Andersen, Stephan Sylvest Keller, Hans Nørgaard Hansen, Anja Boisen

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Abstract

A process has been developed to fabricate discrete three-dimensional microcontainers for oral drug delivery application in Poly-L-Lactic Acid (PLLA) polymer. The method combines hot embossing for the definition of holes in a PLLA film and mechanical punching to penetrate the polymer layer around the holes, after filling them with drug. Here, we demonstrate the fabrication of microcontainers with a diameter of 340 lm and a height of 50 lm. The process is temperature benign so that the compositional integrity of the drug is preserved. It also provides a good flexibility for creating different sizes and shapes of microcontainers. Finally, the process is compatible with roll-to-roll processing that could lead to low cost high volume production. © 2014 Elsevier B.V. All rights reserved.
Original languageEnglish
JournalMicroelectronic Engineering
Volume133
Pages (from-to)104–109
ISSN0167-9317
DOIs
Publication statusPublished - 2015

Keywords

  • Hot embossing
  • Mechanical punching
  • Biodegradable polymer
  • Drug delivery
  • Microcontainers

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