Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

V. Valatas; J. He; Aymeric Marie Christian Rivollier; G. Kolios; K. Kitamura; B. L. Kelsall

doi:10.1038/mi.2012.102

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

V. Valatas
, J. He
, Aymeric Marie Christian Rivollier
, G. Kolios
, K. Kitamura
, B. L. Kelsall

Lund University
National Institutes of Health
Kanazawa University Hospital
Heraklion University Hospital
Democritus University of Thrace

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-deficient mice with differential susceptibility to inflammatory colitis. iTregs represented up to 5% of CD4(+) T cells in mesenteric lymph nodes of less-susceptible C57BL/6RAG2(-/-) mice compared with

Original language	English
Journal	Mucosal Immunology
Volume	6
Issue number	3
Pages (from-to)	601-611
Number of pages	11
ISSN	1933-0219
DOIs	https://doi.org/10.1038/mi.2012.102
Publication status	Published - 2013
Externally published	Yes

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title = "Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis",

abstract = "De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-deficient mice with differential susceptibility to inflammatory colitis. iTregs represented up to 5\% of CD4(+) T cells in mesenteric lymph nodes of less-susceptible C57BL/6RAG2(-/-) mice compared with ",

author = "V. Valatas and J. He and Rivollier, \{Aymeric Marie Christian\} and G. Kolios and K. Kitamura and Kelsall, \{B. L.\}",

year = "2013",

doi = "10.1038/mi.2012.102",

language = "English",

volume = "6",

pages = "601--611",

journal = "Mucosal Immunology",

issn = "1933-0219",

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Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis. / Valatas, V.; He, J.; Rivollier, Aymeric Marie Christian et al.
In: Mucosal Immunology, Vol. 6, No. 3, 2013, p. 601-611.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

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AU - Valatas, V.

AU - He, J.

AU - Rivollier, Aymeric Marie Christian

AU - Kolios, G.

AU - Kitamura, K.

AU - Kelsall, B. L.

PY - 2013

Y1 - 2013

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AB - De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-deficient mice with differential susceptibility to inflammatory colitis. iTregs represented up to 5% of CD4(+) T cells in mesenteric lymph nodes of less-susceptible C57BL/6RAG2(-/-) mice compared with

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DO - 10.1038/mi.2012.102

M3 - Journal article

C2 - 23149660

SN - 1933-0219

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SP - 601

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JO - Mucosal Immunology

JF - Mucosal Immunology

IS - 3

ER -

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

Abstract

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