Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

V. Valatas, J. He, Aymeric Marie Christian Rivollier, G. Kolios, K. Kitamura, B. L. Kelsall

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-deficient mice with differential susceptibility to inflammatory colitis. iTregs represented up to 5% of CD4(+) T cells in mesenteric lymph nodes of less-susceptible C57BL/6RAG2(-/-) mice compared with
Original languageEnglish
JournalMucosal Immunology
Volume6
Issue number3
Pages (from-to)601-611
Number of pages11
ISSN1933-0219
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint Dive into the research topics of 'Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis'. Together they form a unique fingerprint.

Cite this