Horizon scanning the application of probiotics for wildlife

Neus Garcias-Bonet; Anna Roik; Braden Tierney; Francisca C. Garcia; Helena D.M. Villela; Ashley M. Dungan; Kate Quigley; Michael Sweet; Gabriele Berg; Lone Gram; David G. Bourne; Blake Ushijima; Maggie Sogin; Lone Hoj; Gustavo Duarte; Heribert Hirt; Kornelia Smalla; Alexandre S. Rosado; Susana Carvalho; Rebecca Vega Thurber; Maren Ziegler; Christopher E. Mason; Madeleine J.H. van Oppen; Christian R. Voolstra; Raquel S. Peixoto

doi:10.1016/j.tim.2023.08.012

Horizon scanning the application of probiotics for wildlife

Neus Garcias-Bonet, Anna Roik, Braden Tierney, Francisca C. Garcia, Helena D.M. Villela, Ashley M. Dungan, Kate Quigley, Michael Sweet, Gabriele Berg, Lone Gram, David G. Bourne, Blake Ushijima, Maggie Sogin, Lone Hoj, Gustavo Duarte, Heribert Hirt, Kornelia Smalla, Alexandre S. Rosado, Susana Carvalho, Rebecca Vega ThurberMaren Ziegler, Christopher E. Mason, Madeleine J.H. van Oppen, Christian R. Voolstra, Raquel S. Peixoto^*

^*Corresponding author for this work

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Abstract

The provision of probiotics benefits the health of a wide range of organisms, from humans to animals and plants. Probiotics can enhance stress resilience of endangered organisms, many of which are critically threatened by anthropogenic impacts. The use of so-called “probiotics for wildlife” is a nascent application, and the field needs to reflect on standards for its development, testing, validation, risk assessment, and deployment. Here, we identify the main challenges of this emerging intervention and provide a roadmap to validate the effectiveness of wildlife probiotics. We cover the essential use of inert negative controls in trials and the investigation of the probiotic mechanisms of action. We also suggest alternative microbial therapies that could be tested in parallel with the probiotic application. Our recommendations align approaches used for humans, aquaculture, and plants to the emerging concept and use of probiotics for wildlife.

Original language	English
Journal	Trends in Microbiology
Volume	32
Issue number	3
Pages (from-to)	252-269
ISSN	0966-842X
DOIs	https://doi.org/10.1016/j.tim.2023.08.012
Publication status	Published - 2024

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Garcias-Bonet, N., Roik, A., Tierney, B., Garcia, F. C., Villela, H. D. M., Dungan, A. M., Quigley, K., Sweet, M., Berg, G., Gram, L., Bourne, D. G., Ushijima, B., Sogin, M., Hoj, L., Duarte, G., Hirt, H., Smalla, K., Rosado, A. S., Carvalho, S., ... Peixoto, R. S. (2024). Horizon scanning the application of probiotics for wildlife. Trends in Microbiology, 32(3), 252-269. https://doi.org/10.1016/j.tim.2023.08.012

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title = "Horizon scanning the application of probiotics for wildlife",

abstract = "The provision of probiotics benefits the health of a wide range of organisms, from humans to animals and plants. Probiotics can enhance stress resilience of endangered organisms, many of which are critically threatened by anthropogenic impacts. The use of so-called “probiotics for wildlife” is a nascent application, and the field needs to reflect on standards for its development, testing, validation, risk assessment, and deployment. Here, we identify the main challenges of this emerging intervention and provide a roadmap to validate the effectiveness of wildlife probiotics. We cover the essential use of inert negative controls in trials and the investigation of the probiotic mechanisms of action. We also suggest alternative microbial therapies that could be tested in parallel with the probiotic application. Our recommendations align approaches used for humans, aquaculture, and plants to the emerging concept and use of probiotics for wildlife.",

author = "Neus Garcias-Bonet and Anna Roik and Braden Tierney and Garcia, {Francisca C.} and Villela, {Helena D.M.} and Dungan, {Ashley M.} and Kate Quigley and Michael Sweet and Gabriele Berg and Lone Gram and Bourne, {David G.} and Blake Ushijima and Maggie Sogin and Lone Hoj and Gustavo Duarte and Heribert Hirt and Kornelia Smalla and Rosado, {Alexandre S.} and Susana Carvalho and Thurber, {Rebecca Vega} and Maren Ziegler and Mason, {Christopher E.} and {van Oppen}, {Madeleine J.H.} and Voolstra, {Christian R.} and Peixoto, {Raquel S.}",

year = "2024",

doi = "10.1016/j.tim.2023.08.012",

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Garcias-Bonet, N, Roik, A, Tierney, B, Garcia, FC, Villela, HDM, Dungan, AM, Quigley, K, Sweet, M, Berg, G, Gram, L, Bourne, DG, Ushijima, B, Sogin, M, Hoj, L, Duarte, G, Hirt, H, Smalla, K, Rosado, AS, Carvalho, S, Thurber, RV, Ziegler, M, Mason, CE, van Oppen, MJH, Voolstra, CR & Peixoto, RS 2024, 'Horizon scanning the application of probiotics for wildlife', Trends in Microbiology, vol. 32, no. 3, pp. 252-269. https://doi.org/10.1016/j.tim.2023.08.012

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T1 - Horizon scanning the application of probiotics for wildlife

AU - Garcias-Bonet, Neus

AU - Roik, Anna

AU - Tierney, Braden

AU - Garcia, Francisca C.

AU - Villela, Helena D.M.

AU - Dungan, Ashley M.

AU - Quigley, Kate

AU - Sweet, Michael

AU - Berg, Gabriele

AU - Gram, Lone

AU - Bourne, David G.

AU - Ushijima, Blake

AU - Sogin, Maggie

AU - Hoj, Lone

AU - Duarte, Gustavo

AU - Hirt, Heribert

AU - Smalla, Kornelia

AU - Rosado, Alexandre S.

AU - Carvalho, Susana

AU - Thurber, Rebecca Vega

AU - Ziegler, Maren

AU - Mason, Christopher E.

AU - van Oppen, Madeleine J.H.

AU - Voolstra, Christian R.

AU - Peixoto, Raquel S.

PY - 2024

Y1 - 2024

N2 - The provision of probiotics benefits the health of a wide range of organisms, from humans to animals and plants. Probiotics can enhance stress resilience of endangered organisms, many of which are critically threatened by anthropogenic impacts. The use of so-called “probiotics for wildlife” is a nascent application, and the field needs to reflect on standards for its development, testing, validation, risk assessment, and deployment. Here, we identify the main challenges of this emerging intervention and provide a roadmap to validate the effectiveness of wildlife probiotics. We cover the essential use of inert negative controls in trials and the investigation of the probiotic mechanisms of action. We also suggest alternative microbial therapies that could be tested in parallel with the probiotic application. Our recommendations align approaches used for humans, aquaculture, and plants to the emerging concept and use of probiotics for wildlife.

AB - The provision of probiotics benefits the health of a wide range of organisms, from humans to animals and plants. Probiotics can enhance stress resilience of endangered organisms, many of which are critically threatened by anthropogenic impacts. The use of so-called “probiotics for wildlife” is a nascent application, and the field needs to reflect on standards for its development, testing, validation, risk assessment, and deployment. Here, we identify the main challenges of this emerging intervention and provide a roadmap to validate the effectiveness of wildlife probiotics. We cover the essential use of inert negative controls in trials and the investigation of the probiotic mechanisms of action. We also suggest alternative microbial therapies that could be tested in parallel with the probiotic application. Our recommendations align approaches used for humans, aquaculture, and plants to the emerging concept and use of probiotics for wildlife.

U2 - 10.1016/j.tim.2023.08.012

DO - 10.1016/j.tim.2023.08.012

M3 - Journal article

C2 - 37758552

SN - 0966-842X

VL - 32

SP - 252

EP - 269

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 3

ER -

Horizon scanning the application of probiotics for wildlife

Abstract

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