Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat

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  • Author: Zepeda Mendoza, M. Lisandra

    University of Copenhagen, Denmark

  • Author: Xiong, Zijun

    Chinese Academy of Sciences, China

  • Author: Escalera-Zamudio, Marina

    Leibniz Institute for Zoo and Wildlife Research, Germany

  • Author: Runge, Anne Kathrine

    University of Copenhagen, Denmark

  • Author: Thézé, Julien

    University of Oxford, United Kingdom

  • Author: Streicker, Daniel

    University of Glasgow, United Kingdom

  • Author: Frank, Hannah K.

    Stanford University, United States

  • Author: Loza-Rubio, Elizabeth

    Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Mexico

  • Author: Liu, Shengmao

    BGI-Shenzhen , China

  • Author: Ryder, Oliver A.

    San Diego Zoo’s Institute for Conservation Research, United States

  • Author: Samaniego Castruita, José Alfredo

    University of Copenhagen, Denmark

  • Author: Katzourakis, Aris

    University of Oxford, United Kingdom

  • Author: Pacheco, George

    University of Copenhagen, Denmark

  • Author: Taboada, Blanca

    Universidad Nacional Autonoma de Mexico, Mexico

  • Author: Löber, Ulrike

    Leibniz Institute for Zoo and Wildlife Research, Germany

  • Author: Pybus, Oliver G

    University of Oxford, United Kingdom

  • Author: Li, Yang

    BGI-Shenzhen , China

  • Author: Rojas-Anaya, Edith

    Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Mexico

  • Author: Bohmann, Kristine

    University of Copenhagen, Denmark

  • Author: Carmona Baez, Aldo

    National Autonomous University of Mexico, Mexico

  • Author: Arias, Carlos F.

    Universidad Nacional Autonoma de Mexico, Mexico

  • Author: Liu, Shiping

    BGI-Shenzhen , China

  • Author: Greenwood, Alex D.

    Leibniz Institute for Zoo and Wildlife Research, Germany

  • Author: Bertelsen, Mads F.

    Copenhagen Zoo, Denmark

  • Author: White, Nicole E

    Curtin University of Technology, Australia

  • Author: Bunce, Michael

    Curtin University of Technology, Australia

  • Author: Zhang, Guojie

    University of Copenhagen, Denmark

  • Author: Sicheritz-Pontén, Thomas

    Department of Bio and Health Informatics, Technical University of Denmark, Denmark

  • Author: Gilbert, M. Thomas P.

    Norwegian University of Science and Technology, Norway

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Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.
Original languageEnglish
JournalNature Ecology & Evolution
Volume2
Pages (from-to)659-668
ISSN2397-334X
DOIs
Publication statusPublished - 2018

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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