TY - JOUR
T1 - Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat
AU - Zepeda Mendoza, M. Lisandra
AU - Xiong, Zijun
AU - Escalera-Zamudio, Marina
AU - Runge, Anne Kathrine
AU - Thézé, Julien
AU - Streicker, Daniel
AU - Frank, Hannah K.
AU - Loza-Rubio, Elizabeth
AU - Liu, Shengmao
AU - Ryder, Oliver A.
AU - Samaniego Castruita, Jose Alfredo
AU - Katzourakis, Aris
AU - Pacheco, George
AU - Taboada, Blanca
AU - Löber, Ulrike
AU - Pybus, Oliver G.
AU - Li, Yang
AU - Rojas-Anaya, Edith
AU - Bohmann, Kristine
AU - Carmona Baez, Aldo
AU - Arias, Carlos F.
AU - Liu, Shiping
AU - Greenwood, Alex D.
AU - Bertelsen, Mads F.
AU - White, Nicole E.
AU - Bunce, Michael
AU - Zhang, Guojie
AU - Sicheritz-Pontén, Thomas
AU - Gilbert, M. P.Thomas
N1 - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
PY - 2018
Y1 - 2018
N2 - Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.
AB - Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.
U2 - 10.1038/s41559-018-0476-8
DO - 10.1038/s41559-018-0476-8
M3 - Journal article
C2 - 29459707
SN - 2397-334X
VL - 2
SP - 659
EP - 668
JO - Nature Ecology & Evolution
JF - Nature Ecology & Evolution
ER -