Histidine methyltransferase for increased peptide and protein stability

Jonas Laurberg Simonsen; Cristina Hernández Rollán; Jakob Blæsbjerg Hoof; Morten Helge Hauberg Nørholm; Tanveer Signh Batth; Jesper Velgaard Olsen; Katja Salomon Johansen; Søren Brander

Histidine methyltransferase for increased peptide and protein stability

Jonas Laurberg Simonsen (Inventor)
, Cristina Hernández Rollán (Inventor)
, Jakob Blæsbjerg Hoof (Inventor)
, Morten Helge Hauberg Nørholm (Inventor)
, Tanveer Signh Batth (Inventor)
, Jesper Velgaard Olsen (Inventor)
, Katja Salomon Johansen (Inventor)
, Søren Brander (Inventor)

Research output: Patent

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Abstract

The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

Original language	English
IPC	C12N 15/ 80 A I
Patent number	WO2023194390
Filing date	08/04/2022
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	08/04/2022
Priority number	EP20220167491
Publication status	Published - 12 Oct 2023

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title = "Histidine methyltransferase for increased peptide and protein stability",

abstract = "The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.",

author = "Simonsen, \{Jonas Laurberg\} and Roll{\'a}n, \{Cristina Hern{\'a}ndez\} and Hoof, \{Jakob Bl{\ae}sbjerg\} and N{\o}rholm, \{Morten Helge Hauberg\} and Batth, \{Tanveer Signh\} and Olsen, \{Jesper Velgaard\} and Johansen, \{Katja Salomon\} and S{\o}ren Brander",

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day = "12",

language = "English",

type = "Patent",

note = "WO2023194390; C12N 15/ 80 A I",

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T1 - Histidine methyltransferase for increased peptide and protein stability

AU - Simonsen, Jonas Laurberg

AU - Rollán, Cristina Hernández

AU - Hoof, Jakob Blæsbjerg

AU - Nørholm, Morten Helge Hauberg

AU - Batth, Tanveer Signh

AU - Olsen, Jesper Velgaard

AU - Johansen, Katja Salomon

AU - Brander, Søren

PY - 2023/10/12

Y1 - 2023/10/12

N2 - The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

AB - The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

M3 - Patent

M1 - WO2023194390

Y2 - 2022/04/08

ER -

Histidine methyltransferase for increased peptide and protein stability

Abstract

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