Histidine methyltransferase for increased peptide and protein stability

Jonas Laurberg Simonsen; Cristina Hernández Rollán; Jakob Blæsbjerg Hoof; Morten Helge Hauberg Nørholm; Tanveer Signh Batth; Jesper Velgaard Olsen; Katja Salomon Johansen; Søren Brander

Histidine methyltransferase for increased peptide and protein stability

Jonas Laurberg Simonsen (Inventor), Cristina Hernández Rollán (Inventor), Jakob Blæsbjerg Hoof (Inventor), Morten Helge Hauberg Nørholm (Inventor), Tanveer Signh Batth (Inventor), Jesper Velgaard Olsen (Inventor), Katja Salomon Johansen (Inventor), Søren Brander (Inventor)

Research output: Patent

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Abstract

The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

Original language	English
IPC	C12N 15/ 80 A I
Patent number	WO2023194390
Filing date	08/04/2022
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	08/04/2022
Priority number	EP20220167491
Publication status	Published - 12 Oct 2023

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title = "Histidine methyltransferase for increased peptide and protein stability",

abstract = "The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.",

author = "Simonsen, {Jonas Laurberg} and Roll{\'a}n, {Cristina Hern{\'a}ndez} and Hoof, {Jakob Bl{\ae}sbjerg} and N{\o}rholm, {Morten Helge Hauberg} and Batth, {Tanveer Signh} and Olsen, {Jesper Velgaard} and Johansen, {Katja Salomon} and S{\o}ren Brander",

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T1 - Histidine methyltransferase for increased peptide and protein stability

AU - Simonsen, Jonas Laurberg

AU - Rollán, Cristina Hernández

AU - Hoof, Jakob Blæsbjerg

AU - Nørholm, Morten Helge Hauberg

AU - Batth, Tanveer Signh

AU - Olsen, Jesper Velgaard

AU - Johansen, Katja Salomon

AU - Brander, Søren

PY - 2023/10/12

Y1 - 2023/10/12

N2 - The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

AB - The present invention relates to an enzyme exhibiting histidine N-methyltransferase activity, a microbial cell comprising a gene encoding such enzyme, and use of this enzyme for producing a target peptide or protein having a methylated N-terminal histidine residue.

M3 - Patent

M1 - WO2023194390

Y2 - 2022/04/08

ER -

Histidine methyltransferase for increased peptide and protein stability

Abstract

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