Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates

Gregorz Mloston, Agnieszka Majchrazak, Alexander Erich Eugen Senning, Inger Søtofte

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

2,2,4,4-Tetramethyl-3-thioxocyclobutanone (8b) easily reacts with gaseous chlorine to yield the stable alpha-chloro sulfenyl chloride 10. The same product was obtained when 8b was treated either with phosphorus pentachloride (PCl5) or sulfuryl chloride (SO2Cl2) in CCl4 solution. Sulfur dichloride (SCl2) reacts with 8b to give the alpha-chloro thiosulfenyl chloride 12 along with an almost equimolar amount of the trisulfide 13b. The less reactive disulfur dichloride (S2Cl2) was shown to react slowly with 8b and the symmetrical tetrasulfide 15 was found as the exclusive product. The pure thiosulfenyl chloride 12 added to adamantanethione (8e) yielded the unsymmetrical trisulfide 13c. When 12 was treated with thioacetic acid, the acetylated trisulfide 17 was formed in high yield. "Unzipping" reactions with the acetylated disulfide 16 and trisulfide 17 with morpholine in THF at -40 degreesC led to the formation of mixtures of two sulfur-rich heterocycles identified as the pentathiepane 6b and the hexathiepane 7b. A mixture of analogous products was obtained when alpha-chloro sulfenyl chloride 10 was treated with sodium sulfide in anhydrous THF at -40 degreesC. The formation of 6b and 7b is believed to occur via the intermediate dithiirane 1b and/or the isomeric thiosulfine 2b. In the case of 17 the reaction starts probably with the formation of a nonisolable tetrathiane 18b as presented in Scheme 5.
Original languageEnglish
JournalJournal of organic chemistry
Volume67
Issue number16
Pages (from-to)5690-5695
ISSN0022-3263
Publication statusPublished - 2002

Cite this

Mloston, G., Majchrazak, A., Senning, A. E. E., & Søtofte, I. (2002). Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates. Journal of organic chemistry, 67(16), 5690-5695.
Mloston, Gregorz ; Majchrazak, Agnieszka ; Senning, Alexander Erich Eugen ; Søtofte, Inger. / Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates. In: Journal of organic chemistry. 2002 ; Vol. 67, No. 16. pp. 5690-5695.
@article{d203d00aa3fa489cabd6795e3a7e4ce8,
title = "Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates",
abstract = "2,2,4,4-Tetramethyl-3-thioxocyclobutanone (8b) easily reacts with gaseous chlorine to yield the stable alpha-chloro sulfenyl chloride 10. The same product was obtained when 8b was treated either with phosphorus pentachloride (PCl5) or sulfuryl chloride (SO2Cl2) in CCl4 solution. Sulfur dichloride (SCl2) reacts with 8b to give the alpha-chloro thiosulfenyl chloride 12 along with an almost equimolar amount of the trisulfide 13b. The less reactive disulfur dichloride (S2Cl2) was shown to react slowly with 8b and the symmetrical tetrasulfide 15 was found as the exclusive product. The pure thiosulfenyl chloride 12 added to adamantanethione (8e) yielded the unsymmetrical trisulfide 13c. When 12 was treated with thioacetic acid, the acetylated trisulfide 17 was formed in high yield. {"}Unzipping{"} reactions with the acetylated disulfide 16 and trisulfide 17 with morpholine in THF at -40 degreesC led to the formation of mixtures of two sulfur-rich heterocycles identified as the pentathiepane 6b and the hexathiepane 7b. A mixture of analogous products was obtained when alpha-chloro sulfenyl chloride 10 was treated with sodium sulfide in anhydrous THF at -40 degreesC. The formation of 6b and 7b is believed to occur via the intermediate dithiirane 1b and/or the isomeric thiosulfine 2b. In the case of 17 the reaction starts probably with the formation of a nonisolable tetrathiane 18b as presented in Scheme 5.",
author = "Gregorz Mloston and Agnieszka Majchrazak and Senning, {Alexander Erich Eugen} and Inger S{\o}tofte",
year = "2002",
language = "English",
volume = "67",
pages = "5690--5695",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "16",

}

Mloston, G, Majchrazak, A, Senning, AEE & Søtofte, I 2002, 'Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates', Journal of organic chemistry, vol. 67, no. 16, pp. 5690-5695.

Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates. / Mloston, Gregorz; Majchrazak, Agnieszka; Senning, Alexander Erich Eugen; Søtofte, Inger.

In: Journal of organic chemistry, Vol. 67, No. 16, 2002, p. 5690-5695.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates

AU - Mloston, Gregorz

AU - Majchrazak, Agnieszka

AU - Senning, Alexander Erich Eugen

AU - Søtofte, Inger

PY - 2002

Y1 - 2002

N2 - 2,2,4,4-Tetramethyl-3-thioxocyclobutanone (8b) easily reacts with gaseous chlorine to yield the stable alpha-chloro sulfenyl chloride 10. The same product was obtained when 8b was treated either with phosphorus pentachloride (PCl5) or sulfuryl chloride (SO2Cl2) in CCl4 solution. Sulfur dichloride (SCl2) reacts with 8b to give the alpha-chloro thiosulfenyl chloride 12 along with an almost equimolar amount of the trisulfide 13b. The less reactive disulfur dichloride (S2Cl2) was shown to react slowly with 8b and the symmetrical tetrasulfide 15 was found as the exclusive product. The pure thiosulfenyl chloride 12 added to adamantanethione (8e) yielded the unsymmetrical trisulfide 13c. When 12 was treated with thioacetic acid, the acetylated trisulfide 17 was formed in high yield. "Unzipping" reactions with the acetylated disulfide 16 and trisulfide 17 with morpholine in THF at -40 degreesC led to the formation of mixtures of two sulfur-rich heterocycles identified as the pentathiepane 6b and the hexathiepane 7b. A mixture of analogous products was obtained when alpha-chloro sulfenyl chloride 10 was treated with sodium sulfide in anhydrous THF at -40 degreesC. The formation of 6b and 7b is believed to occur via the intermediate dithiirane 1b and/or the isomeric thiosulfine 2b. In the case of 17 the reaction starts probably with the formation of a nonisolable tetrathiane 18b as presented in Scheme 5.

AB - 2,2,4,4-Tetramethyl-3-thioxocyclobutanone (8b) easily reacts with gaseous chlorine to yield the stable alpha-chloro sulfenyl chloride 10. The same product was obtained when 8b was treated either with phosphorus pentachloride (PCl5) or sulfuryl chloride (SO2Cl2) in CCl4 solution. Sulfur dichloride (SCl2) reacts with 8b to give the alpha-chloro thiosulfenyl chloride 12 along with an almost equimolar amount of the trisulfide 13b. The less reactive disulfur dichloride (S2Cl2) was shown to react slowly with 8b and the symmetrical tetrasulfide 15 was found as the exclusive product. The pure thiosulfenyl chloride 12 added to adamantanethione (8e) yielded the unsymmetrical trisulfide 13c. When 12 was treated with thioacetic acid, the acetylated trisulfide 17 was formed in high yield. "Unzipping" reactions with the acetylated disulfide 16 and trisulfide 17 with morpholine in THF at -40 degreesC led to the formation of mixtures of two sulfur-rich heterocycles identified as the pentathiepane 6b and the hexathiepane 7b. A mixture of analogous products was obtained when alpha-chloro sulfenyl chloride 10 was treated with sodium sulfide in anhydrous THF at -40 degreesC. The formation of 6b and 7b is believed to occur via the intermediate dithiirane 1b and/or the isomeric thiosulfine 2b. In the case of 17 the reaction starts probably with the formation of a nonisolable tetrathiane 18b as presented in Scheme 5.

M3 - Journal article

VL - 67

SP - 5690

EP - 5695

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 16

ER -

Mloston G, Majchrazak A, Senning AEE, Søtofte I. Highly sulfurated heterocycles via dithiiranes and trithietanes as key intermediates. Journal of organic chemistry. 2002;67(16):5690-5695.