Highly Sensitive Polymer-based Cantilever-sensors for DNA Detection

Montserrat Gomez, Maria Nordström, M. Alvarez, J. Tamayo, L.M. Lechuga, Anja Boisen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    We present a technology for the fabrication of cantilever arrays aimed to develop an integrated biosensor microsystem. The fabrication process is based on spin coating of the photosensitive polymer and near-ultraviolet exposure. Arrays of up to 33 microcantilevers are fabricated in the novel polymer material SU-8. The low Young's modulus of the polymer, 40 times lower than that of silicon, enables to improve the sensitivity of the sensor device for target detection. The mechanical properties of SU-8 cantilevers, such as spring constant, resonant frequency and quality factor are characterized as a function of the dimensions and the medium. The devices have been tested for measurement of the adsorption of single stranded DNA and subsequent interstitial adsorption of lateral spacer molecules. We demonstrate that sensitivity is enhanced by a factor of six compared to that of commercial silicon nitride cantilevers. (c) 2005 Elsevier B.V. All rights reserved.
    Original languageEnglish
    JournalUltramicroscopy
    Volume105
    Issue number1-4
    Pages (from-to)215-222
    ISSN0304-3991
    DOIs
    Publication statusPublished - 2005
    Event6th International Conference on Scanning Probe Microscopy, Sensors and Nanostructures - Beijing, China
    Duration: 24 May 200426 May 2004
    Conference number: 6

    Conference

    Conference6th International Conference on Scanning Probe Microscopy, Sensors and Nanostructures
    Number6
    CountryChina
    CityBeijing
    Period24/05/200426/05/2004

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