Highly sensitive biosensing based on interference from light scattering in capillary tubes

H.S. Sørensen; N.B. Larsen; J.C. Latham; D.J. Bornhop; Peter E. Andersen

doi:10.1063/1.2356380

Highly sensitive biosensing based on interference from light scattering in capillary tubes

H.S. Sørensen, N.B. Larsen, J.C. Latham, D.J. Bornhop, Peter E. Andersen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Human IgG interactions with surface bound protein A are monitored label-free using microinterferometric backscatter detection. An electromagnetic wave-based model is developed and used to quantitatively describe the change in interference pattern as a consequence of the molecular interaction with the affinity layer on the fused silica capillary. Within the framework of the model it is of paramount importance to establish a valid stop criterion for the infinite summations involved in the fringe pattern computations. The high sensitivity towards surface changes, ease of changing the surface chemistry to other specific interacting layers, and simplicity of the optical sensor make this technique a powerful tool in biosensing. (c) 2006 American Institute of Physics.

Original language	English
Journal	Applied Physics Letters
Volume	89
Issue number	15
Pages (from-to)	151108
Number of pages	3
ISSN	0003-6951
DOIs	https://doi.org/10.1063/1.2356380
Publication status	Published - 2006

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title = "Highly sensitive biosensing based on interference from light scattering in capillary tubes",

abstract = "Human IgG interactions with surface bound protein A are monitored label-free using microinterferometric backscatter detection. An electromagnetic wave-based model is developed and used to quantitatively describe the change in interference pattern as a consequence of the molecular interaction with the affinity layer on the fused silica capillary. Within the framework of the model it is of paramount importance to establish a valid stop criterion for the infinite summations involved in the fringe pattern computations. The high sensitivity towards surface changes, ease of changing the surface chemistry to other specific interacting layers, and simplicity of the optical sensor make this technique a powerful tool in biosensing. (c) 2006 American Institute of Physics. ",

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AU - Sørensen, H.S.

AU - Larsen, N.B.

AU - Latham, J.C.

AU - Bornhop, D.J.

AU - Andersen, Peter E.

N1 - This article may be downloaded for personal use only. Any other use requires prior permission of the author and the publisher

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N2 - Human IgG interactions with surface bound protein A are monitored label-free using microinterferometric backscatter detection. An electromagnetic wave-based model is developed and used to quantitatively describe the change in interference pattern as a consequence of the molecular interaction with the affinity layer on the fused silica capillary. Within the framework of the model it is of paramount importance to establish a valid stop criterion for the infinite summations involved in the fringe pattern computations. The high sensitivity towards surface changes, ease of changing the surface chemistry to other specific interacting layers, and simplicity of the optical sensor make this technique a powerful tool in biosensing. (c) 2006 American Institute of Physics.

AB - Human IgG interactions with surface bound protein A are monitored label-free using microinterferometric backscatter detection. An electromagnetic wave-based model is developed and used to quantitatively describe the change in interference pattern as a consequence of the molecular interaction with the affinity layer on the fused silica capillary. Within the framework of the model it is of paramount importance to establish a valid stop criterion for the infinite summations involved in the fringe pattern computations. The high sensitivity towards surface changes, ease of changing the surface chemistry to other specific interacting layers, and simplicity of the optical sensor make this technique a powerful tool in biosensing. (c) 2006 American Institute of Physics.

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VL - 89

SP - 151108

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 15

ER -

Highly sensitive biosensing based on interference from light scattering in capillary tubes

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