Highly Selective Liquid-Phase Benzylation of Anisole with Solid-Acid Zeolite Catalysts

Raju Poreddy, Saravanamurugan Shunmugavel, Anders Riisager

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Zeolites were evaluated as solid acid catalysts for the liquid-phase benzylation of anisole with benzyl alcohol, benzyl bromide, and benzyl chloride at 80 °C. Among the examined zeolites, H-mordenite-10 (H-MOR-10) demonstrated particular high activity (>99 %) and excellent selectivity (>96 %) to the monobenzylated products, ortho/para benzyl anisole, using benzyl alcohol as reagent (anisole/alcohol molar ratio = 28). Analogous reactions with benzyl halides resulted in lower yields of the desired monobenzylated products. The conversion of benzyl alcohol was confirmed to be proportional to the amount of added H-MOR-10, and the linear free-energy relationship relating the conversion of substituted benzyl alcohol and substituent constants as well as the orientation effect of substituents of anisole on the distribution of ortho/para/meta isomers was evaluated.
Original languageEnglish
JournalTopics in catalysis
Issue number14
Pages (from-to)1053-1061
Number of pages9
Publication statusPublished - 2015


  • Solid-acid catalysis
  • Zeolites
  • Benzyl alcohol
  • Aromatic benzylation
  • Substituted anisole

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