High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms

Mikael Engmark, Mikael Rørdam Andersen, Andreas Hougaard Laustsen, Jigar Patel, Eric Sullivan, Federico De Masi, Christian Skjødt Hansen, Jens Vindahl Kringelum, Bruno Lomonte, José María Gutiérrez, Ole Lund

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    Abstract

    Insight into the molecular details of polyclonal antivenom antibody specificity is a prerequisite for accurate prediction of cross-reactivity and can provide a basis for design of novel antivenoms. In this work, a highthroughput approach was applied to characterize linear elements in epitopes in 82 toxins from four African mamba and three neurotoxic cobra snakes obtained from public databases.
    Original languageEnglish
    Publication date2016
    Number of pages1
    Publication statusPublished - 2016
    EventThe 12th Congress of the Pan-American Section of the International Society on Toxinology: Toxins by the Beach - Deauville Beach Resort, Miami Beach, United States
    Duration: 18 Sept 201623 Sept 2016
    Conference number: 12
    http://ist2016.wixsite.com/2016

    Conference

    ConferenceThe 12th Congress of the Pan-American Section of the International Society on Toxinology
    Number12
    LocationDeauville Beach Resort
    Country/TerritoryUnited States
    CityMiami Beach
    Period18/09/201623/09/2016
    Internet address

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