High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms

Mikael Engmark; Mikael Rørdam Andersen; Andreas Hougaard Laustsen; Jigar Patel; Eric Sullivan; Federico De Masi; Christian Skjødt Hansen; Jens Vindahl Kringelum; Bruno Lomonte; José María Gutiérrez; Ole Lund

High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms

Mikael Engmark, Mikael Rørdam Andersen, Andreas Hougaard Laustsen, Jigar Patel, Eric Sullivan, Federico De Masi, Christian Skjødt Hansen, Jens Vindahl Kringelum, Bruno Lomonte, José María Gutiérrez, Ole Lund

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Abstract

Insight into the molecular details of polyclonal antivenom antibody specificity is a prerequisite for accurate prediction of cross-reactivity and can provide a basis for design of novel antivenoms. In this work, a highthroughput approach was applied to characterize linear elements in epitopes in 82 toxins from four African mamba and three neurotoxic cobra snakes obtained from public databases.

Original language	English
Publication date	2016
Number of pages	1
Publication status	Published - 2016
Event	The 12th Congress of the Pan-American Section of the International Society on Toxinology: Toxins by the Beach - Deauville Beach Resort, Miami Beach, United States Duration: 18 Sept 2016 → 23 Sept 2016 Conference number: 12 http://ist2016.wixsite.com/2016

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Conference	The 12th Congress of the Pan-American Section of the International Society on Toxinology
Number	12
Location	Deauville Beach Resort
Country/Territory	United States
City	Miami Beach
Period	18/09/2016 → 23/09/2016
Internet address	http://ist2016.wixsite.com/2016

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High throughput epitope profiling of snake venom toxins unveiling the complexity of antigen antibody interactions of antivenomsFinal published version, 7.84 MB

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The 12th Congress of the Pan-American Section of the International Society on Toxinology
Engmark, M. (Participant)
18 Sept 2016
Activity: Attending an event › Participating in or organising workshops, courses, seminars etc.

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Engmark, M., Andersen, M. R., Laustsen, A. H., Patel, J., Sullivan, E., De Masi, F., Hansen, C. S., Kringelum, J. V., Lomonte, B., Gutiérrez, J. M., & Lund, O. (2016). High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms. Poster session presented at The 12th Congress of the Pan-American Section of the International Society on Toxinology, Miami Beach, Florida, United States.

Engmark, Mikael ; Andersen, Mikael Rørdam ; Laustsen, Andreas Hougaard et al. / High-throughput epitope profiling of snake venom toxins : unveiling the complexity of antigen-antibody interactions of antivenoms. Poster session presented at The 12th Congress of the Pan-American Section of the International Society on Toxinology, Miami Beach, Florida, United States.1 p.

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abstract = "Insight into the molecular details of polyclonal antivenom antibody specificity is a prerequisite for accurate prediction of cross-reactivity and can provide a basis for design of novel antivenoms. In this work, a highthroughput approach was applied to characterize linear elements in epitopes in 82 toxins from four African mamba and three neurotoxic cobra snakes obtained from public databases.",

author = "Mikael Engmark and Andersen, {Mikael R{\o}rdam} and Laustsen, {Andreas Hougaard} and Jigar Patel and Eric Sullivan and {De Masi}, Federico and Hansen, {Christian Skj{\o}dt} and Kringelum, {Jens Vindahl} and Bruno Lomonte and Guti{\'e}rrez, {Jos{\'e} Mar{\'i}a} and Ole Lund",

year = "2016",

language = "English",

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Engmark, M, Andersen, MR, Laustsen, AH, Patel, J, Sullivan, E, De Masi, F, Hansen, CS, Kringelum, JV, Lomonte, B, Gutiérrez, JM & Lund, O 2016, 'High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms', The 12th Congress of the Pan-American Section of the International Society on Toxinology, Miami Beach, United States, 18/09/2016 - 23/09/2016.

High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms. / Engmark, Mikael; Andersen, Mikael Rørdam; Laustsen, Andreas Hougaard et al.
2016. Poster session presented at The 12th Congress of the Pan-American Section of the International Society on Toxinology, Miami Beach, Florida, United States.

Research output: Contribution to conference › Poster › Research › peer-review

TY - CONF

T1 - High-throughput epitope profiling of snake venom toxins

T2 - The 12th Congress of the Pan-American Section of the International Society on Toxinology

AU - Engmark, Mikael

AU - Andersen, Mikael Rørdam

AU - Laustsen, Andreas Hougaard

AU - Patel, Jigar

AU - Sullivan, Eric

AU - De Masi, Federico

AU - Hansen, Christian Skjødt

AU - Kringelum, Jens Vindahl

AU - Lomonte, Bruno

AU - Gutiérrez, José María

AU - Lund, Ole

N1 - Conference code: 12

PY - 2016

Y1 - 2016

N2 - Insight into the molecular details of polyclonal antivenom antibody specificity is a prerequisite for accurate prediction of cross-reactivity and can provide a basis for design of novel antivenoms. In this work, a highthroughput approach was applied to characterize linear elements in epitopes in 82 toxins from four African mamba and three neurotoxic cobra snakes obtained from public databases.

AB - Insight into the molecular details of polyclonal antivenom antibody specificity is a prerequisite for accurate prediction of cross-reactivity and can provide a basis for design of novel antivenoms. In this work, a highthroughput approach was applied to characterize linear elements in epitopes in 82 toxins from four African mamba and three neurotoxic cobra snakes obtained from public databases.

M3 - Poster

Y2 - 18 September 2016 through 23 September 2016

ER -

High-throughput epitope profiling of snake venom toxins: unveiling the complexity of antigen-antibody interactions of antivenoms

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The 12th Congress of the Pan-American Section of the International Society on Toxinology

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