High-throughput epitope identification for snakebite antivenom

Mikael Engmark; Federico De Masi; Andreas Hougaard Laustsen; José María Gutiérrez; Bruno Lomonte; Mikael Rørdam Andersen; Ole Lund

High-throughput epitope identification for snakebite antivenom

Mikael Engmark, Federico De Masi, Andreas Hougaard Laustsen, José María Gutiérrez, Bruno Lomonte, Mikael Rørdam Andersen, Ole Lund

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Abstract

Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A₂s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.

Original language	English
Publication date	2015
Number of pages	1
Publication status	Published - 2015
Event	The International Sustainability Conference 2015 - Falmer, Brighton, United Kingdom Duration: 25 Aug 2015 → 28 Aug 2015 http://www.ist2015.org/

Conference

Conference	The International Sustainability Conference 2015
Country/Territory	United Kingdom
City	Falmer, Brighton
Period	25/08/2015 → 28/08/2015
Internet address	http://www.ist2015.org/

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18th World Congress of the International Society on Toxinology
Mikael Engmark (Participant)
25 Sep 2015 → 30 Sep 2015
Activity: Attending an event › Participating in or organising workshops, courses, seminars etc.

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abstract = "Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families. ",

author = "Mikael Engmark and {De Masi}, Federico and Laustsen, {Andreas Hougaard} and Guti{\'e}rrez, {Jos{\'e} Mar{\'i}a} and Bruno Lomonte and Andersen, {Mikael R{\o}rdam} and Ole Lund",

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language = "English",

note = "The International Sustainability Conference 2015, IST 2015 ; Conference date: 25-08-2015 Through 28-08-2015",

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T1 - High-throughput epitope identification for snakebite antivenom

AU - Engmark, Mikael

AU - De Masi, Federico

AU - Laustsen, Andreas Hougaard

AU - Gutiérrez, José María

AU - Lomonte, Bruno

AU - Andersen, Mikael Rørdam

AU - Lund, Ole

PY - 2015

Y1 - 2015

N2 - Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.

AB - Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.

M3 - Poster

T2 - The International Sustainability Conference 2015

Y2 - 25 August 2015 through 28 August 2015

ER -

High-throughput epitope identification for snakebite antivenom

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18th World Congress of the International Society on Toxinology

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