High-throughput epitope identification for snakebite antivenom

Mikael Engmark, Federico De Masi, Andreas Hougaard Laustsen, José María Gutiérrez, Bruno Lomonte, Mikael Rørdam Andersen, Ole Lund

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    Abstract

    Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.
    Original languageEnglish
    Publication date2015
    Number of pages1
    Publication statusPublished - 2015
    EventThe International Sustainability Conference 2015 - Falmer, Brighton, United Kingdom
    Duration: 25 Aug 201528 Aug 2015
    http://www.ist2015.org/

    Conference

    ConferenceThe International Sustainability Conference 2015
    CountryUnited Kingdom
    CityFalmer, Brighton
    Period25/08/201528/08/2015
    Internet address

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