High-throughput automated system for statistical biosensing employing microcantilevers arrays

Filippo Bosco, Ching H. Chen, En T. Hwu, Michael Bache, Stephan Sylvest Keller, Anja Boisen

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    In this paper we present a completely new and fully automated system for parallel microcantilever-based biosensing. Our platform is able to monitor simultaneously the change of resonance frequency (dynamic mode), of deflection (static mode), and of surface roughness of hundreds of cantilevers in a very short time over multiple biochemical reactions. We have proven that our system is capable to measure 900 independent microsensors in less than a second. Here, we report statistical biosensing results performed over a haptens-antibody assay, where complete characterization of the biochemical binding on the cantilever surfaces is obtained with higher accuracy than standard optical lever-based setups.
    Original languageEnglish
    Title of host publicationIEEE 24. International Conference on Micro Electro Mechanical Systems
    PublisherIEEE
    Publication date2011
    Pages877-880
    ISBN (Print)978-1-4244-9632-7
    DOIs
    Publication statusPublished - 2011
    Event24th International Conference on Micro Electro Mechanical Systems - Hilton Cancun Golf & Spa Resort, Cancun, Mexico
    Duration: 23 Jan 201127 Jan 2011
    Conference number: 24
    http://www.ieee-mems2011.org/

    Conference

    Conference24th International Conference on Micro Electro Mechanical Systems
    Number24
    LocationHilton Cancun Golf & Spa Resort
    CountryMexico
    CityCancun
    Period23/01/201127/01/2011
    Internet address

    Keywords

    • Surface roughness
    • Measurement by laser beam
    • Surface treatment
    • Resonant frequency
    • Optical sensors
    • Laser beams

    Cite this

    Bosco, F., Chen, C. H., Hwu, E. T., Bache, M., Keller, S. S., & Boisen, A. (2011). High-throughput automated system for statistical biosensing employing microcantilevers arrays. In IEEE 24. International Conference on Micro Electro Mechanical Systems (pp. 877-880). IEEE. https://doi.org/10.1109/MEMSYS.2011.5734565
    Bosco, Filippo ; Chen, Ching H. ; Hwu, En T. ; Bache, Michael ; Keller, Stephan Sylvest ; Boisen, Anja. / High-throughput automated system for statistical biosensing employing microcantilevers arrays. IEEE 24. International Conference on Micro Electro Mechanical Systems. IEEE, 2011. pp. 877-880
    @inproceedings{1ab17a072dc549b58631c8fb53f3cd38,
    title = "High-throughput automated system for statistical biosensing employing microcantilevers arrays",
    abstract = "In this paper we present a completely new and fully automated system for parallel microcantilever-based biosensing. Our platform is able to monitor simultaneously the change of resonance frequency (dynamic mode), of deflection (static mode), and of surface roughness of hundreds of cantilevers in a very short time over multiple biochemical reactions. We have proven that our system is capable to measure 900 independent microsensors in less than a second. Here, we report statistical biosensing results performed over a haptens-antibody assay, where complete characterization of the biochemical binding on the cantilever surfaces is obtained with higher accuracy than standard optical lever-based setups.",
    keywords = "Surface roughness, Measurement by laser beam, Surface treatment, Resonant frequency, Optical sensors, Laser beams",
    author = "Filippo Bosco and Chen, {Ching H.} and Hwu, {En T.} and Michael Bache and Keller, {Stephan Sylvest} and Anja Boisen",
    year = "2011",
    doi = "10.1109/MEMSYS.2011.5734565",
    language = "English",
    isbn = "978-1-4244-9632-7",
    pages = "877--880",
    booktitle = "IEEE 24. International Conference on Micro Electro Mechanical Systems",
    publisher = "IEEE",
    address = "United States",

    }

    Bosco, F, Chen, CH, Hwu, ET, Bache, M, Keller, SS & Boisen, A 2011, High-throughput automated system for statistical biosensing employing microcantilevers arrays. in IEEE 24. International Conference on Micro Electro Mechanical Systems. IEEE, pp. 877-880, 24th International Conference on Micro Electro Mechanical Systems, Cancun, Mexico, 23/01/2011. https://doi.org/10.1109/MEMSYS.2011.5734565

    High-throughput automated system for statistical biosensing employing microcantilevers arrays. / Bosco, Filippo; Chen, Ching H.; Hwu, En T.; Bache, Michael; Keller, Stephan Sylvest; Boisen, Anja.

    IEEE 24. International Conference on Micro Electro Mechanical Systems. IEEE, 2011. p. 877-880.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

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    AU - Boisen, Anja

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    AB - In this paper we present a completely new and fully automated system for parallel microcantilever-based biosensing. Our platform is able to monitor simultaneously the change of resonance frequency (dynamic mode), of deflection (static mode), and of surface roughness of hundreds of cantilevers in a very short time over multiple biochemical reactions. We have proven that our system is capable to measure 900 independent microsensors in less than a second. Here, we report statistical biosensing results performed over a haptens-antibody assay, where complete characterization of the biochemical binding on the cantilever surfaces is obtained with higher accuracy than standard optical lever-based setups.

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    KW - Measurement by laser beam

    KW - Surface treatment

    KW - Resonant frequency

    KW - Optical sensors

    KW - Laser beams

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    Bosco F, Chen CH, Hwu ET, Bache M, Keller SS, Boisen A. High-throughput automated system for statistical biosensing employing microcantilevers arrays. In IEEE 24. International Conference on Micro Electro Mechanical Systems. IEEE. 2011. p. 877-880 https://doi.org/10.1109/MEMSYS.2011.5734565