High-pulse energy supercontinuum laser for high-resolution spectroscopic photoacoustic imaging of lipids in the 1650-1850 nm region

Manoj Kumar Dasa*, Christos Markos, Michael Maria, Christian Rosenberg Petersen, Peter M. Moselund, Ole Bang

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

424 Downloads (Pure)

Abstract

We propose a cost-effective high-pulse energy supercontinuum (SC) source based on a telecom range diode laser-based amplifier and a few meters of standard single-mode optical fiber, with a pulse energy density as high as ∼25 nJ/nm in the 1650-1850 nm regime (factor >3 times higher than any SC source ever used in this wavelength range). We demonstrate how such an SC source combined with a tunable filter allows high-resolution spectroscopic photoacoustic imaging and the spectroscopy of lipids in the first overtone transition band of C-H bonds (1650-1850 nm). We show the successful discrimination of two different lipids (cholesterol and lipid in adipose tissue) and the photoacoustic cross-sectional scan of lipid-rich adipose tissue at three different locations. The proposed high-pulse energy SC laser paves a new direction towards compact, broadband and cost-effective source for spectroscopic photoacoustic imaging.
Original languageEnglish
Article number#320585
JournalBiomedical Optics Express
Volume9
Issue number4
Number of pages9
ISSN2156-7085
DOIs
Publication statusPublished - 2018

Fingerprint Dive into the research topics of 'High-pulse energy supercontinuum laser for high-resolution spectroscopic photoacoustic imaging of lipids in the 1650-1850 nm region'. Together they form a unique fingerprint.

Cite this