High persister phenotype of Pseudomonas Aeruginosa is associated with increased fitness in cystic fibrosis airways

B. Mojsoska; D. Cameron; J. Haagensen; J. Bartell; L. Sommer; K. Lewis; S. Molin; H. K. Johansen

doi:10.1002/ppul.24152

High persister phenotype of Pseudomonas Aeruginosa is associated with increased fitness in cystic fibrosis airways

B. Mojsoska, D. Cameron, J. Haagensen, J. Bartell, L. Sommer, K. Lewis, S. Molin, H. K. Johansen

Novo Nordisk Foundation Center for Biosustainability

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

Chronic Pseudomonas aeruginosa (PA) lung infections in cystic fibrosis (CF) patients present an infection paradox; antibiotics often fail to fully eradicate antibiotic susceptible bacteria, which success-fully adapt and persist in the lungs of the patients. Our objective is to under-stand why antibiotic treatment fails in CF patients infected with PA. It has been suggested that bacterial persistence is associated with the presence of “persister” subpopulations. Persister bacteria are susceptible cells that survive antibiotic treatment and can resume growth when antibiotics are no longer present, resulting in antibiotic tolerance. We hypothesize that treatment failure may be worsened due to the presence of high persister mutants with significantly increased persister subpopulations in presence of antibiotics

Original language	English
Journal	Pediatric Pulmonology
Volume	53
Issue number	S2
Pages (from-to)	315-315
ISSN	8755-6863
DOIs	https://doi.org/10.1002/ppul.24152
Publication status	Published - 2018
Event	The 32nd Annual North American Cystic Fibrosis Conference - Colorado Convention Center, Denver, United States Duration: 18 Oct 2018 → 20 Oct 2018 Conference number: 32

Conference

Conference	The 32nd Annual North American Cystic Fibrosis Conference
Number	32
Location	Colorado Convention Center
Country/Territory	United States
City	Denver
Period	18/10/2018 → 20/10/2018

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10.1002/ppul.24152

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Cite this

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title = "High persister phenotype of Pseudomonas Aeruginosa is associated with increased fitness in cystic fibrosis airways",

abstract = "Chronic Pseudomonas aeruginosa (PA) lung infections in cystic fibrosis (CF) patients present an infection paradox; antibiotics often fail to fully eradicate antibiotic susceptible bacteria, which success-fully adapt and persist in the lungs of the patients. Our objective is to under-stand why antibiotic treatment fails in CF patients infected with PA. It has been suggested that bacterial persistence is associated with the presence of “persister” subpopulations. Persister bacteria are susceptible cells that survive antibiotic treatment and can resume growth when antibiotics are no longer present, resulting in antibiotic tolerance. We hypothesize that treatment failure may be worsened due to the presence of high persister mutants with significantly increased persister subpopulations in presence of antibiotics",

author = "B. Mojsoska and D. Cameron and J. Haagensen and J. Bartell and L. Sommer and K. Lewis and S. Molin and Johansen, {H. K.}",

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AU - Mojsoska, B.

AU - Cameron, D.

AU - Haagensen, J.

AU - Bartell, J.

AU - Sommer, L.

AU - Lewis, K.

AU - Molin, S.

AU - Johansen, H. K.

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AB - Chronic Pseudomonas aeruginosa (PA) lung infections in cystic fibrosis (CF) patients present an infection paradox; antibiotics often fail to fully eradicate antibiotic susceptible bacteria, which success-fully adapt and persist in the lungs of the patients. Our objective is to under-stand why antibiotic treatment fails in CF patients infected with PA. It has been suggested that bacterial persistence is associated with the presence of “persister” subpopulations. Persister bacteria are susceptible cells that survive antibiotic treatment and can resume growth when antibiotics are no longer present, resulting in antibiotic tolerance. We hypothesize that treatment failure may be worsened due to the presence of high persister mutants with significantly increased persister subpopulations in presence of antibiotics

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