High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid

Hikari A. I. Yoshihara; Emine Can; Magnus Karlsson; Mathilde Hauge Lerche; Juerg Schwitter; Arnaud Comment

doi:10.1039/c6cp00589f

High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid

Hikari A. I. Yoshihara, Emine Can, Magnus Karlsson, Mathilde Hauge Lerche, Juerg Schwitter, Arnaud Comment

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

[1-13C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-13C]pyruvic
acid, unextrapolated solution-state 13C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using
optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.

Original language	English
Journal	Physical Chemistry Chemical Physics
Volume	18
Issue number	18
Pages (from-to)	12409-12413
ISSN	1463-9076
DOIs	https://doi.org/10.1039/c6cp00589f
Publication status	Published - 2016

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title = "High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid",

abstract = "[1-13C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-13C]pyruvicacid, unextrapolated solution-state 13C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable usingoptimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.",

author = "Yoshihara, {Hikari A. I.} and Emine Can and Magnus Karlsson and Lerche, {Mathilde Hauge} and Juerg Schwitter and Arnaud Comment",

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T1 - High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid

AU - Yoshihara, Hikari A. I.

AU - Can, Emine

AU - Karlsson, Magnus

AU - Lerche, Mathilde Hauge

AU - Schwitter, Juerg

AU - Comment, Arnaud

PY - 2016

Y1 - 2016

N2 - [1-13C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-13C]pyruvicacid, unextrapolated solution-state 13C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable usingoptimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.

AB - [1-13C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-13C]pyruvicacid, unextrapolated solution-state 13C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable usingoptimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.

U2 - 10.1039/c6cp00589f

DO - 10.1039/c6cp00589f

M3 - Journal article

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SN - 1463-9076

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SP - 12409

EP - 12413

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 18

ER -

High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid

Abstract

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