High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid

Hikari A. I. Yoshihara, Emine Can, Magnus Karlsson, Mathilde Hauge Lerche, Juerg Schwitter, Arnaud Comment

Research output: Contribution to journalJournal articleResearchpeer-review


[1-13C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-13C]pyruvic
acid, unextrapolated solution-state 13C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using
optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
Original languageEnglish
JournalPhysical Chemistry Chemical Physics
Issue number18
Pages (from-to)12409-12413
Publication statusPublished - 2016

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