High-affinity human leucocyte antigen class I binding variola-derived peptides induce CD4(+) T cell responses more than 30 years post-vaccinia virus vaccination

M. Wang, Sheila Tuyet Tang, Ole Lund, M. H. Dziegiel, S. Buus, M. H. Claesson

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Interferon-gamma secreting T lymphocytes against pox virus-derived synthetic 9-mer peptides were tested by enzyme-linked immunospot in peripheral blood of individuals vaccinated with vaccinia virus more than 30 years ago. The peptides were characterized biochemically as high-affinity human leucocyte antigen (HLA) class I binders (K-D
    Original languageEnglish
    JournalClinical and Experimental Immunology
    Volume155
    Issue number3
    Pages (from-to)441-446
    ISSN0009-9104
    DOIs
    Publication statusPublished - 2009

    Keywords

    • smallpox virus
    • HLA class II
    • peptide
    • vaccine
    • HLA class I

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