Hierarchies in control

Peter Ruhdal Jensen, A. A. Van Der Gugten, M. Bier, W. C. Van Heeswijk, J. Rohwer, D. Molenaar, M. Van Workum, P. Richard, B. Teusink, B. Bakker, B. N. Kholodenko, H. V. Westerhoff

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The living cell functions by virtue of an enormous number of different processes. It is one of the most difficult challenges of modern biology to elucidate how all those processes are coordinated quantitatively so as to lead to a viable system with optimal responses to various changes in the environment. The biochemical and biophysical processes of the living cell do not constitute a network with random connections. In this paper we shall discuss that cell function is organized in hierarchical substructures. We will briefly touch on the topics of (i) metabolic control and regulated gene expression, (ii) time dependent metabolism in intact yeast cells, and (iii) metabolite channelling.
    Original languageEnglish
    JournalJournal of Biological Systems
    Volume3
    Issue number1
    Pages (from-to)139-144
    Number of pages6
    ISSN0218-3390
    Publication statusPublished - 1995

    Keywords

    • CONTROL THEORY
    • GENE EXPRESSION
    • GENETICS
    • HIERARCHICAL CONTROL
    • MATHEMATICAL MODELS AND SIMULATION
    • METABOLISM
    • METABOLITE CHANNELING
    • PRIMARY
    • 03502, Genetics - General
    • 04500, Mathematical biology and statistical methods
    • 10515, Biophysics - Biocybernetics
    • 13002, Metabolism - General metabolism and metabolic pathways
    • Computational Biology
    • Genetics
    • Mathematical Biology
    • Metabolism
    • Models and Simulations

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