Hierarchical control of electron-transfer

Hans V. Westerhoff, Peter Ruhdal Jensen, Louis Egger, Wally C. van Heeswijk, Rob van Spanning, Boris N. Kholodenko, Jacky L. Snoep

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    In this chapter the role of electron transfer in determining the behaviour of the ATP synthesising enzyme in E. coli is analysed. It is concluded that the latter enzyme lacks control because of special properties of the electron transfer components. These properties range from absence of a strong back pressure by the protonmotive force on the rate of electron transfer to hierarchical regulation of the expression of the gens that encode the electron transfer proteins as a response to changes in the bioenergetic properties of the cell.The discussion uses Hierarchical Control Analysis as a paradigm. This allows one to analyse a complex system of regulatory interactions in terms of the importance of the contributing factors.
    Original languageEnglish
    Title of host publicationBiological Electron-transfer chains: genetics, composition and mode of operation
    Place of PublicationThe Netherlands
    PublisherKluwer Academic Publishers - Nato series
    Publication date1997
    Publication statusPublished - 1997

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