In this chapter the role of electron transfer in determining the behaviour of the ATP synthesising enzyme in E. coli is analysed. It is concluded that the latter enzyme lacks control because of special properties of the electron transfer components. These properties range from absence of a strong back pressure by the protonmotive force on the rate of electron transfer to hierarchical regulation of the expression of the gens that encode the electron transfer proteins as a response to changes in the bioenergetic properties of the cell.The discussion uses Hierarchical Control Analysis as a paradigm. This allows one to analyse a complex system of regulatory interactions in terms of the importance of the contributing factors.
|Title of host publication||Biological Electron-transfer chains: genetics, composition and mode of operation|
|Place of Publication||The Netherlands|
|Publisher||Kluwer Academic Publishers - Nato series|
|Publication status||Published - 1997|