HExpoChem: a systems biology resource to explore human exposure to chemicals

Olivier Taboureau, Ulrik Plesner Jacobsen, Christian Gram Kalhauge, Stefan Daniel Edsgard, Olga Rigina, Ramneek Gupta, Karine Marie Laure Audouze

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Summary: Humans are exposed to diverse hazardous chemicals daily. Although an exposure to these chemicals is suspected to have adverse effects on human health, mechanistic insights into how they interact with the human body are still limited. Therefore, acquisition of curated data and development of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical–protein interactions have been enriched with a quality-scored human protein–protein interaction network, a protein–protein association network and a chemical–chemical interaction network, thus allowing the study of environmental chemicals through formation of protein complexes and phenotypic outcomes enrichment. Availability: HExpoChem is available at http://www.cbs.dtu.dk/services/HExpoChem-1.0/. Contact: karine@cbs.dtu.dk Supplementary information: Supplementary data are available at Bioinformatics online.
    Original languageEnglish
    JournalBioinformatics
    Volume29
    Issue number9
    Pages (from-to)1231-1232
    ISSN1367-4803
    DOIs
    Publication statusPublished - 2013

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