Hesseltins B–G, novel meroterpenoids from a new Penicillium species

Richard Kerry Phipps; Charlotte Held Gotfredsen; Søren R. Paludan; Jens Christian Frisvad; Kathrine Eriksen; Bent O. Petersen; Jens Øllgaard Duus; Thomas Ostenfeld Larsen

doi:10.1016/j.tetlet.2010.11.140

Hesseltins B–G, novel meroterpenoids from a new Penicillium species

Richard Kerry Phipps, Charlotte Held Gotfredsen, Søren R. Paludan, Jens Christian Frisvad, Kathrine Eriksen, Bent O. Petersen, Jens Øllgaard Duus, Thomas Ostenfeld Larsen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.

Original language	English
Journal	Tetrahedron Letters
Volume	52
Issue number	5
Pages (from-to)	598-601
ISSN	0040-4039
DOIs	https://doi.org/10.1016/j.tetlet.2010.11.140
Publication status	Published - 2011

Keywords

Antiviral
Penicillium
Meroterpenoid
Photoisomerism
Hesseltin

Access to Document

10.1016/j.tetlet.2010.11.140

OpenUrl availability

Full text

Cite this

@article{879bd3c5f2e64b789211629f9e2e9126,

title = "Hesseltins B–G, novel meroterpenoids from a new Penicillium species",

abstract = "Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.",

keywords = "Antiviral, Penicillium, Meroterpenoid, Photoisomerism, Hesseltin",

author = "Phipps, {Richard Kerry} and Gotfredsen, {Charlotte Held} and Paludan, {S{\o}ren R.} and Frisvad, {Jens Christian} and Kathrine Eriksen and Petersen, {Bent O.} and Duus, {Jens {\O}llgaard} and Larsen, {Thomas Ostenfeld}",

year = "2011",

doi = "10.1016/j.tetlet.2010.11.140",

language = "English",

volume = "52",

pages = "598--601",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Pergamon Press",

number = "5",

}

TY - JOUR

T1 - Hesseltins B–G, novel meroterpenoids from a new Penicillium species

AU - Phipps, Richard Kerry

AU - Gotfredsen, Charlotte Held

AU - Paludan, Søren R.

AU - Frisvad, Jens Christian

AU - Eriksen, Kathrine

AU - Petersen, Bent O.

AU - Duus, Jens Øllgaard

AU - Larsen, Thomas Ostenfeld

PY - 2011

Y1 - 2011

N2 - Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.

AB - Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.

KW - Antiviral

KW - Penicillium

KW - Meroterpenoid

KW - Photoisomerism

KW - Hesseltin

U2 - 10.1016/j.tetlet.2010.11.140

DO - 10.1016/j.tetlet.2010.11.140

M3 - Journal article

SN - 0040-4039

VL - 52

SP - 598

EP - 601

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

ER -

Hesseltins B–G, novel meroterpenoids from a new Penicillium species

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this