Hesseltins B–G, novel meroterpenoids from a new Penicillium species

Richard Kerry Phipps, Charlotte Held Gotfredsen, Søren R. Paludan, Jens Christian Frisvad, Kathrine Eriksen, Bent O. Petersen, Jens Øllgaard Duus, Thomas Ostenfeld Larsen

Research output: Contribution to journalJournal articleResearchpeer-review


Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.
Original languageEnglish
JournalTetrahedron Letters
Issue number5
Pages (from-to)598-601
Publication statusPublished - 2011


  • Antiviral
  • Penicillium
  • Meroterpenoid
  • Photoisomerism
  • Hesseltin

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