TY - JOUR
T1 - Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the Picornaviridae
AU - Chard, Louisa S.
AU - Bordeleau, Marie-Eve
AU - Pelletier, J.
AU - Tanaka, J.
AU - Belsham, Graham
PY - 2006
Y1 - 2006
N2 - The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.
AB - The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.
U2 - 10.1099/vir.0.81546-0
DO - 10.1099/vir.0.81546-0
M3 - Journal article
C2 - 16528042
SN - 0022-1317
VL - 87
SP - 927
EP - 936
JO - Journal of General Virology
JF - Journal of General Virology
IS - Part 4
ER -
