Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

Ulla Birgitte Vogel, Vibeke Andersen, Jane Christensen, Kim Overvad, Anne Tjønneland

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Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis. Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated. Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55). Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.
Original languageEnglish
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number3
Pages (from-to)282-285
Publication statusPublished - 2011

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