Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis. Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated. Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55). Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - 2011|
Vogel, U. B., Andersen, V., Christensen, J., Overvad, K., & Tjønneland, A. (2011). Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study. European Journal of Gastroenterology and Hepatology, 23(3), 282-285. https://doi.org/10.1097/MEG.0b013e3283417f76