Heme metabolism in stress regulation and protein production: from Cinderella to a key player

José Luis Martinez Ruiz, D. Petranovic, Jens Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review


Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.
Original languageEnglish
Issue number2
Pages (from-to)112-115
Number of pages4
Publication statusPublished - 2016


  • Heme biosynthesis
  • Cell stress
  • Yeast cell factories
  • Protein production
  • Hap1

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