HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Frederik Otzen Bagger; Nicolas Rapin; Kim Theilgaard-Mönch; Bogumil Kaczkowski; Lina A. Thoren; Johan Jendholm; Ole Winther; Bo Torben Porse

doi:10.1093/nar/gks1021

HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Frederik Otzen Bagger, Nicolas Rapin, Kim Theilgaard-Mönch, Bogumil Kaczkowski, Lina A. Thoren, Johan Jendholm, Ole Winther, Bo Torben Porse

Department of Applied Mathematics and Computer Science

University of Copenhagen

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Abstract

The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.

Original language	English
Journal	Nucleic Acids Research
Volume	41
Issue number	D1
Pages (from-to)	D1034–D1039
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gks1021
Publication status	Published - 2013

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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title = "HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis",

abstract = "The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.",

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AU - Theilgaard-Mönch, Kim

AU - Kaczkowski, Bogumil

AU - Thoren, Lina A.

AU - Jendholm, Johan

AU - Winther, Ole

AU - Porse, Bo Torben

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AB - The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.

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JF - Nucleic Acids Research

IS - D1

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HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Abstract

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