Health promoting compounds in vegetables and fruits:: A systematic approach for identifying plant components with impact on human health

K. Brandt; L.P. Christensen; J. Hansen-Møller; S.L. Hansen; J. Haraldsdottir; L. Jespersen; S. Purup; A. Karazmi; Vibeke Barkholt; Hanne Frøkiær; M. Købæk-Larsen

doi:10.1016/j.tifs.2003.12.003

Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health

K. Brandt, L.P. Christensen, J. Hansen-Møller, S.L. Hansen, J. Haraldsdottir, L. Jespersen, S. Purup, A. Karazmi, Vibeke Barkholt, Hanne Frøkiær, M. Købæk-Larsen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.

Original language	English
Journal	Trends in Food Science & Technology
Volume	15
Issue number	7-8
Pages (from-to)	384-393
ISSN	0924-2244
DOIs	https://doi.org/10.1016/j.tifs.2003.12.003
Publication status	Published - 2004

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Brandt, K., Christensen, L. P., Hansen-Møller, J., Hansen, S. L., Haraldsdottir, J., Jespersen, L., Purup, S., Karazmi, A., Barkholt, V., Frøkiær, H., & Købæk-Larsen, M. (2004). Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health. Trends in Food Science & Technology, 15(7-8), 384-393. https://doi.org/10.1016/j.tifs.2003.12.003

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Brandt, K, Christensen, LP, Hansen-Møller, J, Hansen, SL, Haraldsdottir, J, Jespersen, L, Purup, S, Karazmi, A, Barkholt, V, Frøkiær, H & Købæk-Larsen, M 2004, 'Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health', Trends in Food Science & Technology, vol. 15, no. 7-8, pp. 384-393. https://doi.org/10.1016/j.tifs.2003.12.003

TY - JOUR

T1 - Health promoting compounds in vegetables and fruits:

T2 - A systematic approach for identifying plant components with impact on human health

AU - Brandt, K.

AU - Christensen, L.P.

AU - Hansen-Møller, J.

AU - Hansen, S.L.

AU - Haraldsdottir, J.

AU - Jespersen, L.

AU - Purup, S.

AU - Karazmi, A.

AU - Barkholt, Vibeke

AU - Frøkiær, Hanne

AU - Købæk-Larsen, M.

PY - 2004

Y1 - 2004

N2 - Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.

AB - Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.

U2 - 10.1016/j.tifs.2003.12.003

DO - 10.1016/j.tifs.2003.12.003

M3 - Journal article

SN - 0924-2244

VL - 15

SP - 384

EP - 393

JO - Trends in Food Science & Technology

JF - Trends in Food Science & Technology

IS - 7-8