Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation

Nya Mehnwolo Boayue, Gábor Csifcsák, Oula Puonti, Axel Thielscher, Matthias Mittner

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the electric fields induced by different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.
Original languageEnglish
Article number704
JournalF1000Research
Volume7
Number of pages15
ISSN2046-1402
DOIs
Publication statusPublished - 2018

Keywords

  • Head models
  • Computational modelling
  • Magnetic resonance imaging (MRI)
  • Major depressive disorder (MDD)
  • Non-invasive brain stimulation (NIBS)
  • Transcranial direct current stimulation (tDCS)
  • Transcranial magnetic stimulation (TMS)
  • Volume conduction model

Cite this

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title = "Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation",
abstract = "During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the electric fields induced by different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.",
keywords = "Head models, Computational modelling, Magnetic resonance imaging (MRI), Major depressive disorder (MDD), Non-invasive brain stimulation (NIBS), Transcranial direct current stimulation (tDCS), Transcranial magnetic stimulation (TMS), Volume conduction model",
author = "Boayue, {Nya Mehnwolo} and G{\'a}bor Csifcs{\'a}k and Oula Puonti and Axel Thielscher and Matthias Mittner",
year = "2018",
doi = "10.12688/f1000research.15125.2",
language = "English",
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journal = "F1000Research",
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Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation. / Boayue, Nya Mehnwolo; Csifcsák, Gábor; Puonti, Oula; Thielscher, Axel; Mittner, Matthias.

In: F1000Research, Vol. 7, 704, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation

AU - Boayue, Nya Mehnwolo

AU - Csifcsák, Gábor

AU - Puonti, Oula

AU - Thielscher, Axel

AU - Mittner, Matthias

PY - 2018

Y1 - 2018

N2 - During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the electric fields induced by different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.

AB - During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the electric fields induced by different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.

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KW - Computational modelling

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KW - Major depressive disorder (MDD)

KW - Non-invasive brain stimulation (NIBS)

KW - Transcranial direct current stimulation (tDCS)

KW - Transcranial magnetic stimulation (TMS)

KW - Volume conduction model

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JO - F1000Research

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