Harnessing the nutriceutics in early-stage breast cancer: mechanisms, combinational therapy, and drug delivery

Pavithra Pradeep Prabhu, Barsha Mohanty, Cynthia Lizzie Lobo, Sri Renukadevi Balusamy*, Amitha Shetty, Haribalan Perumalsamy, Manohar Mahadev, Ivan Mijakovic, Akhilesh Dubey*, Priyanka Singh*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Abstract

Background: Breast cancer (BC) is a significant health challenge, ranking as the second leading cause of cancer-related death and the primary cause of mortality among women aged 45 to 55. Early detection is crucial for optimal prognosis. Among various treatment options available for cancer, chemotherapy remains the predominant approach. However, its patient-friendliness is hindered by cytotoxicity, adverse effects, multi-drug resistance, potential for recurrence, and high costs. This review explores extensively studied phytomolecules, elucidating their molecular mechanisms. It also emphasizes the importance of combination therapy, highlighting recent advancements in the exploration of diverse drug delivery systems and novel routes of administration. The regulatory considerations are crucial in translating these approaches into clinical practices. Results: Consequently, there is growing interest in exploring the relationship between diet, cancer, and complementary and alternative medicine (CAM) in cancer chemotherapy. Phytochemicals like berberine, curcumin, quercetin, lycopene, sulforaphane, resveratrol, epigallocatechin gallate, apigenin, genistein, thymoquinone have emerged as promising candidates due to their pleiotropic actions on target cells through multiple mechanisms with minimal toxicity effects. This review focuses on extensively studied phytomolecules, elucidating their molecular mechanisms. It also emphasizes the importance of combination therapy, highlighting recent advancements in the exploration of diverse drug delivery systems and novel routes of administration. The regulatory considerations are crucial in translating these approaches into clinical practices. Conclusion: The present review provides a comprehensive understanding of the molecular mechanisms, coupled with well-designed clinical trials and adherence to regulatory guidelines, which pave the way for nutrition-based combination therapies to become a frontline approach in early-stage BC treatment. Graphical Abstract: (Figure presented.)

Original languageEnglish
Article number574
JournalJournal of Nanobiotechnology
Volume22
Issue number1
ISSN1477-3155
DOIs
Publication statusPublished - 2024

Keywords

  • Breast cancer
  • Chemotherapy
  • Complementary and alternative system of medicine
  • Dietary phytomolecules
  • Novel drug delivery systems
  • Nutrition-based combination therapy

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