Harnessing off-target effects

Gaye Saginc, Franziska Voellmy, Rune Linding

Research output: Contribution to journalJournal articleResearchpeer-review


The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
Original languageEnglish
JournalNature Chemical Biology
Issue number12
Pages (from-to)1204-1205
Number of pages2
Publication statusPublished - 2017

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