Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.

Jens Breinholt; Anders Kjær; Carl Erik Olsen; Birgitte R. Rassing; Connie N. Rosendahl

doi:10.3891/acta.chem.scand.51-1241

Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.

Jens Breinholt
, Anders Kjær
, Carl Erik Olsen
, Birgitte R. Rassing
, Connie N. Rosendahl

Novo Nordisk Foundation
University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C₂₅H₃₂O₅) and dihydrohamigerone (C₂₅H₃₄O₅), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units.

Original language	English
Journal	Acta Chemica Scandinavica
Volume	51
Issue number	12
Pages (from-to)	1241-1244
ISSN	0904-213X
DOIs	https://doi.org/10.3891/acta.chem.scand.51-1241
Publication status	Published - 1997

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title = "Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.",

abstract = "The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units.",

author = "Jens Breinholt and Anders Kj{\ae}r and Olsen, \{Carl Erik\} and Rassing, \{Birgitte R.\} and Rosendahl, \{Connie N.\}",

year = "1997",

doi = "10.3891/acta.chem.scand.51-1241",

language = "English",

volume = "51",

pages = "1241--1244",

journal = "Acta Chemica Scandinavica",

issn = "0904-213X",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.

AU - Breinholt, Jens

AU - Kjær, Anders

AU - Olsen, Carl Erik

AU - Rassing, Birgitte R.

AU - Rosendahl, Connie N.

PY - 1997

Y1 - 1997

N2 - The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units.

AB - The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units.

U2 - 10.3891/acta.chem.scand.51-1241

DO - 10.3891/acta.chem.scand.51-1241

M3 - Journal article

SN - 0904-213X

VL - 51

SP - 1241

EP - 1244

JO - Acta Chemica Scandinavica

JF - Acta Chemica Scandinavica

IS - 12

ER -

Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.

Abstract

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