Hamigerone and Dihydrohamigerone: Two Acetate derived, antifungal metabolites from Hamigera avellanea.

Jens Breinholt, Anders Kjær, Carl Erik Olsen, Birgitte R. Rassing, Connie N. Rosendahl

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units.
    Original languageEnglish
    JournalActa Chemica Scandinavica
    Volume51
    Issue number12
    Pages (from-to)1241-1244
    ISSN0904-213X
    DOIs
    Publication statusPublished - 1997

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