Hacking CD/DVD/Blu-ray for Biosensing

Edwin En-Te Hwu*, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano-resolution x-, z-axis and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under non-disclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bio-applications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Repurposing low-cost and high-performance OPUs may spread micro and nanoscale biosensing research from research labs to citizen scientists around the globe.
Original languageEnglish
JournalACS Sensors
Volume3
Issue number7
Pages (from-to)1222-1232
Number of pages11
ISSN2379-3694
DOIs
Publication statusPublished - 2018

Bibliographical note

This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Keywords

  • Compact disc (CD)
  • Digital versatile disc (DVD)
  • Blu-ray
  • Optical pickup-unit (OPU)
  • Nanobio imaging
  • Cytometer
  • Optical tweezer
  • DNA chip
  • Fluorescence excitation emission matrix
  • Medical diagnostics

Cite this

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title = "Hacking CD/DVD/Blu-ray for Biosensing",
abstract = "The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano-resolution x-, z-axis and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under non-disclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bio-applications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Repurposing low-cost and high-performance OPUs may spread micro and nanoscale biosensing research from research labs to citizen scientists around the globe.",
keywords = "Compact disc (CD), Digital versatile disc (DVD), Blu-ray, Optical pickup-unit (OPU), Nanobio imaging, Cytometer, Optical tweezer, DNA chip, Fluorescence excitation emission matrix, Medical diagnostics",
author = "Hwu, {Edwin En-Te} and Anja Boisen",
note = "This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.",
year = "2018",
doi = "10.1021/acssensors.8b00340",
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}

Hacking CD/DVD/Blu-ray for Biosensing. / Hwu, Edwin En-Te; Boisen, Anja.

In: ACS Sensors, Vol. 3, No. 7, 2018, p. 1222-1232.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Hacking CD/DVD/Blu-ray for Biosensing

AU - Hwu, Edwin En-Te

AU - Boisen, Anja

N1 - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

PY - 2018

Y1 - 2018

N2 - The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano-resolution x-, z-axis and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under non-disclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bio-applications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Repurposing low-cost and high-performance OPUs may spread micro and nanoscale biosensing research from research labs to citizen scientists around the globe.

AB - The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano-resolution x-, z-axis and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under non-disclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bio-applications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Repurposing low-cost and high-performance OPUs may spread micro and nanoscale biosensing research from research labs to citizen scientists around the globe.

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KW - Digital versatile disc (DVD)

KW - Blu-ray

KW - Optical pickup-unit (OPU)

KW - Nanobio imaging

KW - Cytometer

KW - Optical tweezer

KW - DNA chip

KW - Fluorescence excitation emission matrix

KW - Medical diagnostics

U2 - 10.1021/acssensors.8b00340

DO - 10.1021/acssensors.8b00340

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VL - 3

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JO - ACS Sensors

JF - ACS Sensors

SN - 2379-3694

IS - 7

ER -