Gut microbiota maturity mediates the protective effect of siblings on food allergy

BIS Investigator Group; Yuan Gao; Jakob Stokholm; Martin O’Hely; Anne-Louise Ponsonby; Mimi LK. Tang; Sarath Ranganathan; Richard Saffery; Leonard C. Harrison; Fiona Collier; Lawrence Gray; David Burgner; John Molloy; Peter D. Sly; Susanne Brix; Hanne Frøkiær; Peter Vuillermin

doi:10.1016/j.jaci.2023.02.034

Gut microbiota maturity mediates the protective effect of siblings on food allergy

BIS Investigator Group, Yuan Gao, Jakob Stokholm, Martin O’Hely, Anne-Louise Ponsonby, Mimi LK. Tang, Sarath Ranganathan, Richard Saffery, Leonard C. Harrison, Fiona Collier, Lawrence Gray, David Burgner, John Molloy, Peter D. Sly, Susanne Brix, Hanne Frøkiær, Peter Vuillermin^*

^*Corresponding author for this work

Department of Biotechnology and Biomedicine

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Background: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota.
Objective: We investigated whether having older siblings decreases the risk of Immunoglobulin E (IgE)-mediated food allergy by accelerating the maturation of the infant gut microbiota.
Methods: In a birth cohort assembled using an unselected antenatal sampling frame (n=1074), fecal samples were collected at 1 month, 6 months and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge. We used 16S rRNA gene amplicon sequencing to derive amplicon sequence variants (ASVs). Among a random subcohort (n=323), microbiota-by-age z-scores (MAZ) at each time point were calculated using fecal ASVs to represent the gut microbiota maturation over the first year of life.
Results: A greater number of siblings was associated with a higher MAZ at 1 year of age (β =0.15 per an additional sibling; 95%CI (0.05, 0.24); p=0.003), which was in turn associated with decreased odds of food allergy (OR=0.45; 95%CI (0.33, 0.61); p

Original language	English
Journal	Journal of Allergy and Clinical Immunology
Volume	152
Issue number	3
Pages (from-to)	667-675
ISSN	0091-6749
DOIs	https://doi.org/10.1016/j.jaci.2023.02.034
Publication status	Published - 2023

Keywords

Food allergy
Microbiota maturation
Birth cohort
Siblings

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BIS Investigator Group, Gao, Y., Stokholm, J., O’Hely, M., Ponsonby, A.-L., Tang, M. LK., Ranganathan, S., Saffery, R., Harrison, L. C., Collier, F., Gray, L., Burgner, D., Molloy, J., Sly, P. D., Brix, S., Frøkiær, H., & Vuillermin, P. (2023). Gut microbiota maturity mediates the protective effect of siblings on food allergy. Journal of Allergy and Clinical Immunology, 152(3), 667-675. https://doi.org/10.1016/j.jaci.2023.02.034

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title = "Gut microbiota maturity mediates the protective effect of siblings on food allergy",

abstract = "Background: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. Objective: We investigated whether having older siblings decreases the risk of Immunoglobulin E (IgE)-mediated food allergy by accelerating the maturation of the infant gut microbiota. Methods: In a birth cohort assembled using an unselected antenatal sampling frame (n=1074), fecal samples were collected at 1 month, 6 months and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge. We used 16S rRNA gene amplicon sequencing to derive amplicon sequence variants (ASVs). Among a random subcohort (n=323), microbiota-by-age z-scores (MAZ) at each time point were calculated using fecal ASVs to represent the gut microbiota maturation over the first year of life. Results: A greater number of siblings was associated with a higher MAZ at 1 year of age (β =0.15 per an additional sibling; 95%CI (0.05, 0.24); p=0.003), which was in turn associated with decreased odds of food allergy (OR=0.45; 95%CI (0.33, 0.61); p",

keywords = "Food allergy, Microbiota maturation, Birth cohort, Siblings",

author = "{BIS Investigator Group} and Yuan Gao and Jakob Stokholm and Martin O{\textquoteright}Hely and Anne-Louise Ponsonby and Tang, {Mimi LK.} and Sarath Ranganathan and Richard Saffery and Harrison, {Leonard C.} and Fiona Collier and Lawrence Gray and David Burgner and John Molloy and Sly, {Peter D.} and Susanne Brix and Hanne Fr{\o}ki{\ae}r and Peter Vuillermin",

year = "2023",

doi = "10.1016/j.jaci.2023.02.034",

language = "English",

volume = "152",

pages = "667--675",

journal = "Journal of Allergy and Clinical Immunology",

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BIS Investigator Group, Gao, Y, Stokholm, J, O’Hely, M, Ponsonby, A-L, Tang, MLK, Ranganathan, S, Saffery, R, Harrison, LC, Collier, F, Gray, L, Burgner, D, Molloy, J, Sly, PD, Brix, S, Frøkiær, H & Vuillermin, P 2023, 'Gut microbiota maturity mediates the protective effect of siblings on food allergy', Journal of Allergy and Clinical Immunology, vol. 152, no. 3, pp. 667-675. https://doi.org/10.1016/j.jaci.2023.02.034

TY - JOUR

T1 - Gut microbiota maturity mediates the protective effect of siblings on food allergy

AU - BIS Investigator Group

AU - Gao, Yuan

AU - Stokholm, Jakob

AU - O’Hely, Martin

AU - Ponsonby, Anne-Louise

AU - Tang, Mimi LK.

AU - Ranganathan, Sarath

AU - Saffery, Richard

AU - Harrison, Leonard C.

AU - Collier, Fiona

AU - Gray, Lawrence

AU - Burgner, David

AU - Molloy, John

AU - Sly, Peter D.

AU - Brix, Susanne

AU - Frøkiær, Hanne

AU - Vuillermin, Peter

PY - 2023

Y1 - 2023

N2 - Background: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. Objective: We investigated whether having older siblings decreases the risk of Immunoglobulin E (IgE)-mediated food allergy by accelerating the maturation of the infant gut microbiota. Methods: In a birth cohort assembled using an unselected antenatal sampling frame (n=1074), fecal samples were collected at 1 month, 6 months and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge. We used 16S rRNA gene amplicon sequencing to derive amplicon sequence variants (ASVs). Among a random subcohort (n=323), microbiota-by-age z-scores (MAZ) at each time point were calculated using fecal ASVs to represent the gut microbiota maturation over the first year of life. Results: A greater number of siblings was associated with a higher MAZ at 1 year of age (β =0.15 per an additional sibling; 95%CI (0.05, 0.24); p=0.003), which was in turn associated with decreased odds of food allergy (OR=0.45; 95%CI (0.33, 0.61); p

AB - Background: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. Objective: We investigated whether having older siblings decreases the risk of Immunoglobulin E (IgE)-mediated food allergy by accelerating the maturation of the infant gut microbiota. Methods: In a birth cohort assembled using an unselected antenatal sampling frame (n=1074), fecal samples were collected at 1 month, 6 months and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge. We used 16S rRNA gene amplicon sequencing to derive amplicon sequence variants (ASVs). Among a random subcohort (n=323), microbiota-by-age z-scores (MAZ) at each time point were calculated using fecal ASVs to represent the gut microbiota maturation over the first year of life. Results: A greater number of siblings was associated with a higher MAZ at 1 year of age (β =0.15 per an additional sibling; 95%CI (0.05, 0.24); p=0.003), which was in turn associated with decreased odds of food allergy (OR=0.45; 95%CI (0.33, 0.61); p

KW - Food allergy

KW - Microbiota maturation

KW - Birth cohort

KW - Siblings

U2 - 10.1016/j.jaci.2023.02.034

DO - 10.1016/j.jaci.2023.02.034

M3 - Journal article

C2 - 37150361

SN - 0091-6749

VL - 152

SP - 667

EP - 675

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Gut microbiota maturity mediates the protective effect of siblings on food allergy

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Keywords

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