Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

Hachung Chung; Sünje Johanna Pamp; Jonathan A. Hill; Neeraj K. Surana; Sanna M. Edelman; Erin B. Troy; Nicola C. Reading; Eduardo J. Villablanca; Sen Wang; Jorge R. Mora; Yoshinori Umesaki; Diane Mathis; Christophe Benoist; David A. Relman; Dennis L. Kasper

doi:10.1016/j.cell.2012.04.037

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

Hachung Chung
, Sünje Johanna Pamp
, Jonathan A. Hill
, Neeraj K. Surana
, Sanna M. Edelman
, Erin B. Troy
, Nicola C. Reading
, Eduardo J. Villablanca
, Sen Wang
, Jorge R. Mora
, Yoshinori Umesaki
, Diane Mathis
, Christophe Benoist
, David A. Relman
, Dennis L. Kasper

Massachusetts General Hospital
Yakult Central Institute for Microbiological Research
Massachusetts General Hospital/Harvard Medical School
Brigham and Women’s Hospital
Stanford University School of Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Germ-free mice that lack intestinal microbiota are immunodeficient, with failed maturation of gut immune cells. Inoculation of these mice with either human or rat microbiota does not support gut immunity either, suggesting that mammalian hosts have coevolved with a specific consortium of bacterial species that stimulates intestinal immune maturation.

Original language	English
Journal	Cell
Volume	149
Issue number	7
Pages (from-to)	1578-1593
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2012.04.037
Publication status	Published - 2012
Externally published	Yes

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@article{364fdef61c7845ff8643b7a33cb67f75,

title = "Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota",

abstract = "Germ-free mice that lack intestinal microbiota are immunodeficient, with failed maturation of gut immune cells. Inoculation of these mice with either human or rat microbiota does not support gut immunity either, suggesting that mammalian hosts have coevolved with a specific consortium of bacterial species that stimulates intestinal immune maturation.",

author = "Hachung Chung and Pamp, \{S{\"u}nje Johanna\} and Hill, \{Jonathan A.\} and Surana, \{Neeraj K.\} and Edelman, \{Sanna M.\} and Troy, \{Erin B.\} and Reading, \{Nicola C.\} and Villablanca, \{Eduardo J.\} and Sen Wang and Mora, \{Jorge R.\} and Yoshinori Umesaki and Diane Mathis and Christophe Benoist and Relman, \{David A.\} and Kasper, \{Dennis L.\}",

year = "2012",

doi = "10.1016/j.cell.2012.04.037",

language = "English",

volume = "149",

pages = "1578--1593",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

AU - Chung, Hachung

AU - Pamp, Sünje Johanna

AU - Hill, Jonathan A.

AU - Surana, Neeraj K.

AU - Edelman, Sanna M.

AU - Troy, Erin B.

AU - Reading, Nicola C.

AU - Villablanca, Eduardo J.

AU - Wang, Sen

AU - Mora, Jorge R.

AU - Umesaki, Yoshinori

AU - Mathis, Diane

AU - Benoist, Christophe

AU - Relman, David A.

AU - Kasper, Dennis L.

PY - 2012

Y1 - 2012

N2 - Germ-free mice that lack intestinal microbiota are immunodeficient, with failed maturation of gut immune cells. Inoculation of these mice with either human or rat microbiota does not support gut immunity either, suggesting that mammalian hosts have coevolved with a specific consortium of bacterial species that stimulates intestinal immune maturation.

AB - Germ-free mice that lack intestinal microbiota are immunodeficient, with failed maturation of gut immune cells. Inoculation of these mice with either human or rat microbiota does not support gut immunity either, suggesting that mammalian hosts have coevolved with a specific consortium of bacterial species that stimulates intestinal immune maturation.

U2 - 10.1016/j.cell.2012.04.037

DO - 10.1016/j.cell.2012.04.037

M3 - Journal article

C2 - 22726443

SN - 0092-8674

VL - 149

SP - 1578

EP - 1593

JO - Cell

JF - Cell

IS - 7

ER -

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

Abstract

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